Results 151 to 160 of about 2,009,331 (298)
Petermann Ranges, Northern Territory : explanatory notes
, 1972 1:250 000Available in a compilation of 1st edition BMR explanatory notes on DVD, NTGS Special Publication 3Also downloadable from Geoscience ...
Forman, D. J.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sandover River, Northern Territory : explanatory notes
, 1966 1:250 000Available in a compilation of 1st edition BMR explanatory notes on DVD, NTGS Special Publication 3Also downloadable from Geoscience ...
Nichols, RAH
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Trivialisms about Explanatory Gap
KRITERION – Journal of PhilosophyAbstract A spectre of anti-physicalism haunts philosophy of mind: we seem unable to explain how the phenomenal arises from the physical. Rather than repeat clichés about the profundity of this explanatory gap, in this paper, I defend a set of Trivialisms, which suggest the phenomenal explanatory gap may not be as special as widely ...
openaire +1 more source
Lake Amadeus, Northern Territory : explanatory notes
, 1968 1:250 000Available in a compilation of 1st edition BMR explanatory notes on DVD, NTGS Special Publication 3Also downloadable from Geoscience ...
Cook, PJ
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evolvability: filling the explanatory gap between adaptedness and the long-term mathematical conception of fitness. [PDF]
Biol PhilosBourrat P, Deaven K, Villegas C.
europepmc +1 more source
Green Swamp Well, Northern Territory : explanatory notes
, 1978 1:250 000Available in a compilation of 1st edition BMR explanatory notes on DVD, NTGS Special Publication 3Also downloadable from Geoscience ...
Kennewell, PJ
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source