Results 41 to 50 of about 97,976 (296)

The influences of the TPS model and reading interests on writing skills of explanatory text of class VIII student

, 2018
This research aims to describe the influences of TPS model and reading interest of class VIII student of SMP Negeri 31 Padang about their skills of writing explanatory text. This research type is quantitative research with 2x2 factorial experiment design.
Lidya Atsari, Novia Juita, Agustina, Agustina Agustina   +3 more
core   +3 more sources

The Influence of Discovery Learning Methods and Reading Interest on the Writing Skills of Explanatory Texts

Journal of Languages and Language Teaching
Discovery learning is considered an effective educational method that can engage students and enhance their reading and writing skills. This method encourages students to develop a greater interest in reading and provides ample opportunities for ...
Suci Septa Prima, Abdurahman Abdurahman
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Features of a Patient Portal for Blood Test Results and Patient Health Engagement: Web-Based Pre-Post Experiment

Journal of Medical Internet Research, 2020
BackgroundThe use of patient portals for presenting health-related patient data, such as blood test results, is becoming increasingly important in health practices.
Struikman, Bas, Bol, Nadine, Goedhart, Annelijn, van Weert, Julia C M, Talboom-Kamp, Esther, van Delft, Sanne, Brabers, Anne E M, van Dijk, Liset   +7 more
doaj   +1 more source

Regression analysis and variable selection to determine the key subduction-zone parameters that determine the maximum earthquake magnitude

Earth, Planets and Space, 2023
Large variations in the maximum earthquake magnitude ( $$M_{{\text{max}}}$$ M max ) have been observed among the world’s subduction zones. There is still no universal relationship between $$M_{{\text{max}}}$$ M max and a given subduction-zone parameter ...
Atsushi Nakao, Tatsu Kuwatani, Kenta Ueki, Kenta Yoshida, Taku Yutani, Hideitsu Hino, Shotaro Akaho   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

De l’image narrative à l’image narratrice. Ce que la théorie de Genette fait dire sur Mélusine

Perspectives Médiévales, 2021
It is traditional to speak of the narrativity of an image, as soon as it transposes a narrative, or if it includes elements of temporality. This article proposes to widen the area of competence and the prerogatives of the image: the image would not be ...
Maud Pérez-Simon
doaj   +1 more source

Text-based recommender system with explanatory capabilities

, 2022
Abstract Recommender systems have proven their usefulness both for companies and customers. The former increase their sales and the latter get a more satisfying shopping experience. These systems can benefit from the advent of explainable artificial intelligence, since a well-explained recommendation will be more convincing and may ...
Pablo Pérez-Núñez, Jorge Díez, Antonio Bahamonde, Oscar Luaces   +3 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source