Results 51 to 60 of about 97,976 (296)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

General unsupervised explanatory opinion mining from text data [PDF]

open access: yes, 2013
Due to the abundance and rapid growth of opinionated data on the Web, research on opinion mining and summarization techniques has received a lot of attention from industry and academia.
Kim, Hyun Duk
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

TEAM-PAIR-SOLO TECHNIQUE TO TEACH READING COMPREHENSION OF EXPLANATORY TEXT

open access: yes, 2016
Email: endahworohapsari@rocketmail.com Abstract: The purpose of this research was to investigate the level of the effectiveness of team-pair-solo to teach reading comprehension of explanatory text to Year-X students of “SMA Negeri 8 Pontianak” in ...
Bunau, Eusabinus   +2 more
core   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The role of cognates in reading comprehension: a cognitive perspective [PDF]

open access: yes, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente.Research on cognates has strongly indicated that there is a close relationship ...
Souza, Vilmar Ferreira de
core  

Explanatory constructions in the Altai language (in literary and academic texts) [PDF]

open access: yesSibirskiy filologicheskiy zhurnal, 2020
We analyze the structural and semantic types of Altai polypredicative explanatory construc-tions (in literary and academic texts). Explanatory relations are expressed by two types of constructions: monofinite (with the infinite predicate in the subordinate clause) and bifinite (with the finite predicate in the main and subordinate clauses and their ...
openaire   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

PENGARUH METODE PROJECT BASED LEARNING TERHADAP KEMAMPUAN MENULIS TEKS EKSPLANASI SISWA KELAS VIII SMP NEGERI 1 PENANGGALAN KOTA SUBULUSSALAM

open access: yesSeBaSa
This study aims to compare the writing abilities of students in writing Explanatory Texts using the lecture method and the project-based learning method among eighth-grade students at SMP Negeri 1 Penaggalan for the 2023-2024 academic year.
Nurdiana   +2 more
doaj   +1 more source

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