Results 121 to 130 of about 66,453 (258)

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Functional human skin explants as tools for assessing mast cell activation and inhibition

Frontiers in Allergy
Mast cells are activated through a variety of different receptors to release preformed granules and mediators synthesized de novo. However, the physiology and function of mast cells are not fully understood. Traditional studies of mast cell activation in
Clarence Rachel Villanueva, Keane Barksdale, Tinuola Owolabi, Donavan Bridges, Kristin Chichester, Sarbjit Saini, Eric T. Oliver   +6 more
doaj   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source

Explant of the prelaminar region of the optic nerve viewed via LM and CLSM.

, 2015
As explants are thinner than 300 microns, the penetration of culture medium is sufficient for the survival of the explant for more than a week. A) LM photography of an original 2 x magnification of an explant after 5 days of culture; toluidine blue ...
Antonio Zarzuelo (748015), F. Javier Carreras (748010), David Porcel (748012), Olga Martínez-Agustin (748014), Carlos J. Aranda (748011), Francisco Rodriguez-Hurtado (748013)   +5 more
core   +1 more source

Recovery kinetics of dual AAV-mediated human otoferlin expression

Frontiers in Molecular Neuroscience
Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV)-based approaches. However, timing of transduction, recombination of mRNA, and protein expression with dual hybrid AAV methods ...
Jonathan B. Sellon, Kathy S. So, Kathy S. So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C. Drummond, Peter G. Slade, Peter G. Slade, Ning Pan, Ning Pan, Tyler M. Gibson, Tian Yang, Joseph C. Burns, Adam T. Palermo, Lars Becker, Lars Becker   +15 more
doaj   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Response to In Vitro Micropropagation of Plants with Different Degrees of Variegation of the Commercial Gymnocalycium cv. Fancy (Cactaceae)

Plants
This study aims to establish efficient in vitro propagation protocols for Gymnocalycium cv. Fancy, an ornamental cactus with variegated variants, by evaluating the effects of cytokinin type and explant source on the organogenic response.
Carles Cortés-Olmos, Vladimir Marín Guerra-Sandoval, Carla Guijarro-Real, Benito Pineda, Ana Fita, Adrián Rodríguez-Burruezo   +5 more
doaj   +1 more source

Retrohepatic Vena Cava Encirclement, as Surrogate of Extensive Liver Manipulation During Caval Sparing Hepatectomy, Is a Risk Factor for Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction In liver transplantation (LT) with a caval sparing (CS) approach, the presence of complete encirclement of inferior vena cava (IVC‐E) by hypertrophic segment 1 increases the technical complexity of hepatectomy. Thus, in LT for hepatocellular carcinoma (HCC), It may be suspected that the resulting greater liver manipulation and ...
Riccardo Pravisani, Claudio Bosio, Grazia Conte, Alex Borin, Amedeo Carraro, Federico Mocchegiani, Maria De Martino, Marco Vivarelli, Dario Lorenzin, Umberto Baccarani   +9 more
wiley   +1 more source

Experimental setup and explant boundary conditions.

, 2016
(A) An inverted Nikon Eclipse Ti microscope operating in DIC mode was used to image the fibrin-explant system. Samples were prepared and maintained in either a microscope-mounted ADMET BioTense Bioreactor (as shown in A) or in glass bottom Petri-dishes ...
Maziar Aghvami (2166142), Edward A. Sander (2166145), Aribet M. De Jesus (2166139)   +2 more
core   +1 more source

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Journal of Surgical Oncology, EarlyView.
ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan.
Serkan Sucu, Brian Longbottom, Hassan Aziz   +2 more
wiley   +1 more source