Results 141 to 150 of about 66,453 (258)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Endoscopic small bowel therapies for type 2 diabetes

Nutrition in Clinical Practice, EarlyView.
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel, Zehra Naseem, Prisha Gattu, Stephen Firkins, Roberto Simons‐Linares   +4 more
wiley   +1 more source

Plant responses to iron nutrition with emphasis on the underutilized crop tef (Eragrostis tef): A review

PLANTS, PEOPLE, PLANET, EarlyView.
Iron (Fe) deficiency limits the physical health, cognitive development, and economic output of billions of people globally, especially children and productive‐age women. Tef is an underutilized and stress‐resilient crop, which is becoming popular for its grains containing high bioavailable Fe and has the potential to mitigate Fe deficiency.
Muhammad Numan, David Remington, Ayalew Ligaba‐Osena   +2 more
wiley   +1 more source

Surgical explant of degenerated transcatheter valves: a new type of threat?

Objectives: Transcatheter treatment for valvular heart diseases has markedly expanded its indications due to reduced invasiveness and hospitalization time. Despite favourable results, several peculiar and more frequent shortcomings than in surgical-based
Czerny, Martin, Bidar, Elham, Di Mauro, Michele, Verolino, Giuseppe; id_orcid, Kawczynski, Michal, Heuts, Samuel, Verolino, Giuseppe, Lorusso, Roberto   +7 more
core   +1 more source

Host‐induced silencing of the Minc09294 effector gene impairs Meloidogyne incognita and M. Enterolobii infection

Pest Management Science, EarlyView.
Host‐induced gene silencing of the effector candidate Minc09294 significantly impairs Meloidogyne incognita parasitism, markedly reducing gall formation, reproduction, and the development of specialized giant cells, with partial cross‐species effects on M.
João Pedro Abreu‐Sousa, Thuanne Pires Ribeiro, Daniele Heloisa Pinheiro, Valdeir Junio Vaz Moreira, Luanna Pinheiro Alburquerque Freitas Bezerra, Júlia Moura Rosário Santana, Lays Antunes Teixeira, Maria Eugenia Lisei‐de‐Sa, Deyse Alexandra Rosero Alpala, Manoely Abreu Reis, Isabela Tristan Lourenço‐Tessutti, Leonardo Lima Pepino Macedo, Carolina Vianna Morgante, Maria Cristina Mattar Silva, Marcos Fernando Basso, Janice de Almeida‐Engler, Maria Fatima Grossi‐de‐Sa   +16 more
wiley   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

A Rapid and Highly Effective Protocol for Sporophyte Proliferation of <i>Drynaria roosii</i> and the Potential Regulation Mechanism by Plant Growth Regulators. [PDF]

Plants (Basel)
Han Y, Ren Y, Cao Y, Zhen S, Li X, Wang Y.   +5 more
europepmc   +1 more source

AS1517499 Protects Auditory Hair Cells Against Cisplatin‐Induced Damage In Vitro

Sensory Neuroscience, EarlyView.
AS1517499 alleviates cisplatin‐induced ototoxicity by reducing oxidative stress and apoptosis in cochlear hair cells. AS1517499 pretreatment reduces cisplatin‐induced cellular damage in HEI‐OC1 cells and hair cell loss in cochlear explants, thereby improving cell viability and preserving cochlear hair cells.
Qin Gu, Yue Qiu, Zhijie Fang, Xiaohong Lv, Song Gao, Zhiqiang Lin   +5 more
wiley   +1 more source

When redo-transcatheter aortic valve replacement (TAVR) is not enough: self-expanding TAVR explant and the next frontier of lifetime valve management. [PDF]

J Thorac Dis
Shrouf A, Jabri A, Abdalaziz MH, Villablanca PA.   +3 more
europepmc   +1 more source