Results 51 to 60 of about 66,453 (258)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Trigeminal ganglion explant cultures.

, 2013
(A) Scheme of the double chamber system. (B–D) Trigeminal ganglion explant (TGE) cultures stained with DiI in the axonal compartment (AC) 48 h before imaging: (B) overview and (C, D) typical DiI-positive neurons (solid arrowheads) and neurites ...
Wali Hafezi (323437), Barbara Klupp (323441), Marcus Müller (68469), Nicholas J. C. King (299113), Eva U. Lorentzen (323438), Bodo R. Eing (323439), Joachim E. Kühn (323443), Thomas C. Mettenleiter (245021)   +7 more
core   +1 more source

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, EarlyView.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source

Mortality statistics, censored for explant and transplant.

, 2014
SMOTE: synthetic minority oversampling technique.Mortality statistics, censored for explant and transplant.
Natasha A. Loghmanpour (661124), Marek J. Druzdzel (661125), James F. Antaki (661126)   +2 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

An Efficient Agrobacterium-Mediated Genetic Transformation System for Gene Editing in Strawberry (Fragaria × ananassa)

Plants
The octoploid-cultivated strawberry variety Benihope (Fragaria × ananassa Duch cv. Benihope) is an important commercial plant. It is highly susceptible to different diseases, which ultimately leads to a reduction in yield.
Fatema Akter, Suting Wu, Md Shariful Islam, Htin Kyaw, Jinwen Yang, Mingyue Li, Yuxin Fu, Jinxia Wu   +7 more
doaj   +1 more source

In vitro propagation of Gypsophila pilulifera, an endangered endemic ornamental plant species

Acta Scientiarum Polonorum: Hortorum Cultus, 2022
Gypsophila pilulifera Boiss. & Heldr., an endemic and endangered species is an economically important plant that has a potential used in medicine thank to the saponins it contains. It is also an ornamental plant.
Hatice Ustuner, Ayse Gul Nasırcılar, Mustafa Yavuz, Ramazan Suleyman Gokturk   +3 more
doaj   +1 more source

Shoot formation from explant cultures of fourteen potato cultivars and studies of the cytology and morphology of regenerated plants

, 1985
Plants were regenerated in quantity from cultured excised stem, rachis or leaf pieces of 13 potato (Solarium tuberosum L.) cultivars using modifications of a two-step procedure.
Bright, S. W. J., Wheeler, V. A., Franklin, J., Webb, K. J., Evans, N. E., Foulger, D., Karp, A.   +6 more
core   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

NaHS inhibits gentamicin-induced ototoxicity in mouse cochlear explant.

, 2015
Mouse cochlear explant was isolated and cultured as described in materials and methods. After 24 hours cultured in the incubator, cochlear explant were divided into 3 treatment groups: PBS (control), 80 μM gentamicin (GM) and 80 μM gentamicin + 250 μM ...
Yue Hu (201714), Xiulan Ma (785624), Yaodong Dong (785623), Dongliang Liu (653854)   +3 more
core   +1 more source