Results 121 to 130 of about 3,657,908 (359)

Quantitative Assessment of Gut and Vascular Barriers in TTOP, a Cartridge‐Based Bicompartmental Culture Platform

Advanced Materials Technologies, EarlyView.
The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro, Maria Lombardi, Sabrina Nicolò, Alessandra Maria Anna Rando, Gianfranco Beniamino Fiore, Chiara Foglieni, Monica Soncini   +6 more
wiley   +1 more source

Predicting Axonal Response to Molecular Gradients with a Computational Model of Filopodial Dynamics [PDF]

, 2004
Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia ...
Caton A., Hong K., Meinhardt H., Patel K.   +3 more
core   +3 more sources

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma, Shima Salehi, Michela Anna Polidoro, Matteo Moretti, Marco Rasponi, Silvia Lopa, Paola Occhetta   +6 more
wiley   +1 more source

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas [PDF]

, 2018
FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to pathologies associated with paradoxical ERK1/2 activation in wild-type BRAF cells.
Aplin, Andrew E., Berger, Adam C., Bollag, Gideon, Davies, Michael A., Goldberg, Allison F., Hartsough, Edward J., Knudsen, Karen E., Kugel, Curtis H., Purwin, Timothy J., Schiewer, Matthew J., Vido, Michael J.   +10 more
core   +1 more source

The effects of different combinations and varying concentrations of growth regulators on the regeneration of selected Turkish cultivars of melon [PDF]

, 2013
Cucurbits are an economically important family of plants. The majority of the vegetable production in Turkey, for example, derives from the species beloning to the family Cucurbitaceae. Despite the importance of cucurbits among vegetable crops worldwide,
Cetiner, Selim, Tekdal, Dilek, Çetiner, Selim   +2 more
core   +2 more sources

Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases

Advanced Science, EarlyView.
We present a functional three‐dimensional in‐vivo‐mimicking human colon (3D‐IVM‐HC) model engineered via Freeform Reversible Embedding of Suspended Hydrogels bioprinting with gelatin methacrylate (GelMA)/alginate hydrogels. This 3D non‐animal model replicates crypt‐like architectures, epithelial polarization, and stromal–tumor interactions, showing ...
Jorge Alfonso Tavares‐Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour   +7 more
wiley   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Data on the cost effective surface sterilization method for C.carandas (L.) seeds and callus induction from aseptic seedling

Data in Brief, 2016
Surface sterilization of explant is an important and most sensitive step in plant tissue culture. Inappropriate concentrations of sterilants have lethal effect in cell division and it restricts growth and development of explant.
Bhushan S. Bhadane, Ravindra H. Patil
doaj   +1 more source

Padrões de acúmulo de proteínas e carboidratos durante a embriogênese somática de Acca sellowiana [PDF]

, 2009
The aim of this work was to quantify the protein, starch and total sugars levels during histodifferentiation and development of somatic embryos of Acca sellowiana Berg.
Cangahuala-Inocente, Gabriela Claudia, Guerra, Miguel Pedro, Maldonado, Sara Beatriz, Steiner, Neusa   +3 more
core   +3 more sources

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source