Phosphodiesterase 3 inhibitors boost bone outgrowth
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe+11 more
wiley +1 more source
Skin Explant Cultures: Expression of Cytoplasmic Differentiation Antigens in Outgrowth Cells
Liliane Didierjean+4 more
openalex +1 more source
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis. [PDF]
Lee-Ferris RE+20 more
europepmc +1 more source
Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model. [PDF]
Matsunaga M+7 more
europepmc +1 more source
ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen+9 more
wiley +1 more source
Isolation and Characterization of Cervical Cancer-Associated Mesenchymal Stem Cells From Primary Tumors Using Explant Culture. [PDF]
Singla S+4 more
europepmc +1 more source
Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai+9 more
wiley +1 more source
Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen-associated molecular patterns. [PDF]
Mátis G+9 more
europepmc +1 more source
Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang+8 more
wiley +1 more source