Results 211 to 220 of about 3,657,908 (359)

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions

United European Gastroenterology Journal, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion (PNI), defined as the infiltration of neoplastic cells along nerve fibers and within nerve sheaths, is ...
Martin Lovecek, Esra Dirimtekin, Ingrid Garajová, Giulia Gasparini, Stefano Crippa, Elisa Giovannetti, Dana Sochorova, Carmen Mota Reyes, Ihsan Ekin Demir, Pinar Uysal‐Onganer, on behalf TRANSPAN PNI Group   +10 more
wiley   +1 more source

Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture. [PDF]

Sci Rep
Filion R, St-Georges-Robillard A, Chaudoir H, Ritch S, Ndongo M, Chua XY, Laurent E, Mes-Masson AM, Ajji A, Gervais T.   +9 more
europepmc   +1 more source

An in vitro ovarian explant culture system to examine sex change in a hermaphroditic fish. [PDF]

PeerJ, 2020
Goikoetxea A, Damsteegt EL, Todd EV, McNaughton A, Gemmell NJ, Lokman PM.   +5 more
europepmc   +1 more source

Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture [PDF]

, 2000
Michael W. Epperly, Christine Sikora, S. Defilippi, Jenifer A. Bray, Gary S. Koe, Denny Liggitt, James D. Luketich, Joel S. Greenberger   +7 more
openalex   +1 more source

Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy

Aging Cell, EarlyView.
Senescent cells accumulate extranuclear DNA fragments that are recognized by the cyclic GMP‐AMP synthase (cGAS) and its effector protein stimulator of interferon genes (STING), which promotes expression of SASP and DAMP genes by inducing nuclear factor‐kappa B (NF‐κB) and IFN regulatory factor 3 (IRF3) translocation.
Anna Barkovskaya, Ashley Brauning, Aditi Thambala, Kriti Bhardwaj, Manish Chamoli, Anand Rane, Julie K. Andersen, Amit Sharma   +7 more
wiley   +1 more source

Integrating Cartilage Explant Culture with Simulated Digestion and Hepatic Biotransformation Refines In Vitro Screening of Joint Care Nutraceuticals. [PDF]

Methods Protoc
Crosbie M, Vanderboom K, Souccar-Young J, Pearson W.   +3 more
europepmc   +1 more source

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

Allergy, EarlyView.
Diet‐induced obesity increases transepidermal water loss and compromises barrier function through downregulation of tight junctions and desmosomes. During obesity, MC903 elicits a mixed Th1/2/17 immune response in the skin leading to aggravated ear swelling.
Alicia Martinek, Andrea Deinzer, Roman G. Gerlach, Jana Petzold, Lea Semmler, Christof Vorsatz, Padraic G. Fallon, Christian Schwartz   +7 more
wiley   +1 more source

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis. [PDF]

Sci Adv
Lee-Ferris RE, Okuda K, Galiger JR, Schworer SA, Rogers TD, Dang H, Gilmore R, Edwards C, Crisp G, Nakano S, Cawley AM, Pickles RJ, Gallant SC, Crisci E, Rivier L, Hagood JS, O'Neal WK, Baric RS, Grubb BR, Boucher RC, Randell SH.   +20 more
europepmc   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Isolation and Characterization of Cervical Cancer-Associated Mesenchymal Stem Cells From Primary Tumors Using Explant Culture. [PDF]

Bio Protoc
Singla S, Khurana S, Bagga R, Srinivasan R, Bhattacharyya S.   +4 more
europepmc   +1 more source