Results 231 to 240 of about 3,692,560 (357)

Chronic Low‐Level Lead Exposure Causes Auditory Impairment and Accelerates the Progression of Age‐Related Hearing Loss in C57BL/6J Mice

open access: yesAging Cell, EarlyView.
Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai   +10 more
wiley   +1 more source

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

open access: yesAllergy, EarlyView.
Diet‐induced obesity increases transepidermal water loss and compromises barrier function through downregulation of tight junctions and desmosomes. During obesity, MC903 elicits a mixed Th1/2/17 immune response in the skin leading to aggravated ear swelling.
Alicia Martinek   +7 more
wiley   +1 more source

Opportunities of patient‐derived organoids in drug development

open access: yesBritish Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Skin punch biopsy explant culture for derivation of primary human fibroblasts.

open access: yesJournal of Visualized Experiments, 2013
Malini Vangipuram   +4 more
semanticscholar   +1 more source

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