Results 271 to 280 of about 3,692,560 (357)

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

open access: yesJournal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann   +8 more
wiley   +1 more source

The wide gape of snakes: A comparison of the developing mandibular symphysis in sauropsids

open access: yesJournal of Anatomy, EarlyView.
Our analysis explores the adaptations at the mandibular symphysis required to allow extreme lower jaw mobility in macrostomate snakes taking a comparative approach. Abstract The origin and evolution of snakes has been marked by the acquisition of many morphological and functional novelties, one of which is the possession of a highly kinetic skull ...
Maricci Basa   +3 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

open access: yesJournal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed   +6 more
wiley   +1 more source

Floral stage optimization and immune evasion enhance Agrobacterium‐mediated genome editing in Arabidopsis

open access: yesNew Phytologist, EarlyView.
Summary Agrobacterium‐mediated transformation by floral inoculation (AMT‐FI) enables genetic engineering without tissue culture. It is widely used in the model plant Arabidopsis thaliana, yet its efficiency and broader applicability remain limited. Here, we used a dual‐reporter system (RUBY and hygromycin resistance) to identify key floral stages and ...
Mao‐Sen Liu   +6 more
wiley   +1 more source

Enzymatic Drivers of Cartilage Breakdown: Insights From a Bovine Osteoarthritis Explant Model

open access: yesOrthopaedic Surgery, EarlyView.
A bovine cartilage explant model was developed to simulate early osteoarthritis using matrix‐degrading enzymes. Histological analysis revealed synergistic cartilage damage from MMPs, ADAMTS‐5, and COMP. This ex vivo model offers a reproducible platform to study OA mechanisms and test therapeutic interventions.
Austin Lawrence   +5 more
wiley   +1 more source

Highly efficient transgene‐free ErCas12a RNP‐protoplast genome editing and single‐cell regeneration in Nicotiana benthamiana for glyco‐engineering

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Nicotiana benthamiana serves as a unique platform for biopharmaceutical production, offering advantages such as efficient and scalable protein synthesis. In addition, custom N‐glycans can be engineered on biopharmaceutical glycoproteins. Yet, plant‐native glycosyltransferases and glycoside hydrolases need to be removed to prevent undesired ...
Lukas C. Blumberg   +8 more
wiley   +1 more source

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance

open access: yesPlant Biotechnology Journal, EarlyView.
Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas   +17 more
wiley   +1 more source

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