Results 301 to 310 of about 3,657,908 (359)

Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

The Journal of Physiology, EarlyView.
Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid, Francisco Algaba‐Chueca, Elsa Maymó‐Masip, Mónica Ballesteros, Montse Inglés, Albert Guarque, Nerea Vilanova‐Ricart, Ariadna Prats, Azra Kulovic‐Sissawo, Elisa Weiss, Ursula Hiden, Joan Vendrell, Sonia Fernández‐Veledo, Ana Megía   +13 more
wiley   +1 more source

The first live term birth following uterus transplantation in Australia

Medical Journal of Australia, EarlyView.
Abstract Objective To report the first live birth following uterus transplantation in Australia. Study design Case report. Setting, participant The first participant in the uterus transplantation research study program at the Royal Hospital for Women, the Prince of Wales Hospital, and Westmead Hospital in Sydney.
Rebecca Deans, Brigitte Gerstl, Antonia W Shand, Sarah Lyons, Aaron Budden, Helen L Barrett, Grant Luxton, Mangalee Fernando, Kenneth Yong, Karen Keung, Kaushalya Arulpragasam, Henry Pleass, King Man Wan, Eva Kehag, Jana‐Emily Pittman, Mianna Lotz, Maria Fenn, Erin Nesbitt‐Hawes, Lily Byun, Katrina Tang, Mats Brannstrom, Jason Abbott   +21 more
wiley   +1 more source

Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell‐Based Regeneration

JOR SPINE, Volume 8, Issue 4, December 2025.
Intervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Anja Stirnimann, Leon Schlagenhof, Benjamin Gantenbein, Fabian Ille   +3 more
wiley   +1 more source

Evaluation of Rasna panchaka (indigenous drug) as oxidative stress down-regulator using serum-free explant culture system.

Indian J Pharmacol, 2018
Talluri M, Yathapu SR, Bharatraj DK.
europepmc   +1 more source

FNA biopsy of breast specimens effectively harvests cells for patient‐derived organoids modeling ductal carcinoma in situ

Cancer Cytopathology, Volume 133, Issue 11, November 2025.
Abstract Background Patient‐derived organoids (PDOs) generated from benign breast tissue and breast carcinomas have successfully recapitulated their in vivo counterparts. PDOs model tumorigenesis and allow for screening novel therapeutics personalized to individual patients. However, acquiring cells to generate PDOs is cumbersome.
Julia Ye, Nadine Goldhammer, Poonam Vohra, Shruti Warhadpande, George C. de Castro, Cristian K. Maldonado Rodas, Mark M. Moasser, Kirithiga Ramalingam, Shoko E. Abe, Michael Alvarado, Cheryl Ewing, Karen M. Goodwin, Rita A. Mukhtar, Jasmine M. Wong, Laura J. Esserman, Ronald Balassanian, Jennifer M. Rosenbluth   +16 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, Volume 19, Issue 10, Page 2860-2881, October 2025.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, Volume 19, Issue 10, Page 2797-2821, October 2025.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Medical Materials and Device Innovation: Choosing the Right and Relevant Biological Models

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
Choosing the right disease model is key to safe, effective medical innovation. When models reflect human biology and clinical needs, they improve translation, reduce risk, and accelerate progress. Advances in 3D tissues, organ‐on‐chip, and humanized systems offer exciting opportunities. With thoughtful selection and clinician input, biomedical research
Inge K. Herrmann, Tina Buerki‐Thurnherr   +1 more
wiley   +1 more source

In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of orcine viruses with the respiratory tract [PDF]

, 2007
Favoreel, Herman, Glorieux, Sarah, Nauwynck, Hans, Van Den Broeck, Wim, VAN DER MEULEN, KM, Van Reeth, Kristien   +5 more
core  

A Narrative Review on the Recent Insights Into the Pathogenicity and Potential Role of Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) in the Emergence of “Disease X”

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Following the end of the COVID‐19 global emergency, concern has shifted to “Disease X,” a hypothetical, highly transmissible, and deadly pathogen, and Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a prime candidate for this. This review explores its epidemiology, mutations, transmission, and potential to become
Zubaier Ahmed, Kazi Milenur Rahman Prattay, Sabrina Sharmin, Fatema‐Tuz‐Zohora, Asef Raj, Forhad Bin Faruk, Bagdad Ahmed, Humair Bin Md Omer, Anika Awal Omi, Fazle Rabbi, Nasiba Binte Bahar, Sumiya Sharmin Mou, Mehedi Islam, Eshaba Karim, Md. Elias Al‐Mamun   +14 more
wiley   +1 more source