Results 71 to 80 of about 1,195,586 (290)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Derandomized Construction of Combinatorial Batch Codes

, 2015
Combinatorial Batch Codes (CBCs), replication-based variant of Batch Codes introduced by Ishai et al. in STOC 2004, abstracts the following data distribution problem: $n$ data items are to be replicated among $m$ servers in such a way that any $k$ of the
B Bollobás, C Bujtás, C Bujtás, C Bujtás, C Bujtás, MB Paterson, N Alon, N Alon, N Balachandran, P Erdős, R Motwani, RA Brualdi, S Bhattacharya, W Hoeffding   +13 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Design as interactions of problem framing and problem solving [PDF]

, 2002
This paper introduces a model of framing in design. The model takes into account a reflective nature of designing, and it is based on the interplay between two conceptually distinct knowledge sources – an explicit specification of a problem and a ...
Dzbor, Martin, Zdrahal, Zdenek
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Implementation and Convergence Analysis of Homotopy Perturbation Coupled With Sumudu Transform to Construct Solutions of Local-Fractional PDEs

Fractal and Fractional, 2018
In the present paper, the explicit solutions of some local fractional partial differential equations are constructed through the integration of local fractional Sumudu transform and homotopy perturbation such as local fractional dissipative and damped ...
Kamal Ait Touchent, Zakia Hammouch, Toufik Mekkaoui, Fethi B. M. Belgacem   +3 more
doaj   +1 more source

Theory of small aspect ratio waves in deep water

, 2005
In the limit of small values of the aspect ratio parameter (or wave steepness) which measures the amplitude of a surface wave in units of its wave-length, a model equation is derived from the Euler system in infinite depth (deep water) without potential ...
Benney, Boussinesq, Camassa, Degasperis, Degasperis, Dias, Dullin, Green, Green, J. Leon, Jeffrey, Johnson, Kodama, Korteweg, Kraenkel, Lighthill, M.A. Manna, Manna, Matsuno, Mei, R.A. Kraenkel, Seliger, Taniuti, Vander-Broeck, Whitham, Zakharov   +25 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source