Results 231 to 240 of about 14,288,816 (348)

Robust Conformational Space Exploration of Cyclic Peptides by Combining Different MD Protocols and Force Fields. [PDF]

J Chem Theory Comput
Murail S, Sawmynaden J, Zemirli A, Jusot M, Pietrucci F, Chomilier J, Tufféry P, Stratmann D.   +7 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Coarse-grained solvent-free model for computer simulation of self-assembled amphiphiles. [PDF]

Sci Rep
Bhowmick S, Saha J.
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Explicit minimisers for anisotropic Riesz energies. [PDF]

Calc Var Partial Differ Equ
Frank RL, Mateu J, Mora MG, Rondi L, Scardia L, Verdera J.   +5 more
europepmc   +1 more source

Perfect Recursive Reconciliation System (Triality Engine): Perfect Bidirectional Dyadic +Z Architecture (Explicit Fractal–Directional Form)

Kornhaus, Devin
openalex   +1 more source

Explicit form of quaternion modular embeddings

, 1995
Let \(\mathbb{B}\) be an indefinite quaternion algebra over \(\mathbb{Q}\), and let \({\mathcal O}\) be an Eichler order of \(\mathbb{B}\). If \(Nr\) denotes the reduced norm of \(\mathbb{B}\), then \(\Gamma = \{\gamma \in {\mathcal O} \mid Nr (\gamma) = 1\}\) is a discrete subgroup of \(\mathbb{B}^{(1)}\cong SL_2 (\mathbb{R})\), and the quotient ...
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Development of explicit definitions of potentially inappropriate prescriptions for antidiabetic drugs in people with type 2 diabetes: A Delphi survey and consensus meeting. [PDF]

PLoS One
Gerard E, Bugday D, Calafiore M, Baran J, Gautier S, Henry H, Decaudin B, Lemaitre M, Baclet N, Quindroit P, Vambergue A, Beuscart JB.   +11 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source