Results 131 to 140 of about 1,127,197 (289)

Intelligibility, comprehensibility, and accentedness in L2 speech: Effects of explicit pronunciation instruction and task-supported language teaching

open access: yesCanadian Journal of Applied Linguistics
While explicit instruction helps L2 learners in pronunciation learning (Lee et al., 2015; Saito & Plonsky, 2019), task-based language teaching enhances second language (L2) pronunciation development when learners are exposed to tasks that vary in ...
Joshua Gordon
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Monthly Bulletin of the State Department of Public Instruction, 1952

open access: yes, 1952
Publication information Monthly during school yearFloyd Souders and Mrs. Hazel Bixby Appointed to State Board of Education Children's Dental Health Day To Be Observed on February 4 Handbook for School Board Members Published by League of Kansas ...
Kansas State Department of Public Instruction
core  

Developing pragmatic awareness of suggestions in the EFL classroom: A focus on instructional effects

open access: yesCanadian Journal of Applied Linguistics, 2007
The role of instruction to develop learners’ pragmatic competence in both second and foreign language contexts has recently motivated a great deal of research.
Alicia Martínez-Flor, Eva Alcón Soler
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Kansas Schools, Vol. 23 [1966-1967]

open access: yes, 1966
Publication information Monthly during school yearW.C. Kampschroeder Appointed State Superintendent of Kansas Adel Throckmorton Steps Down After 18 Years in Office Kampschroeder Appointed Superintendent Adel Throclnnorton Education Is an Exceptionally ...
Kansas State Department of Public Instruction
core  

The influence of an intensive and integrated place-based professional development program on teachers' views of the nature of science

open access: yesCurrent Issues in Education, 2014
Appropriate views of the nature of science are vital to scientific literacy yet rarely taught in US schools primarily due to naïve NOS views held by teachers. Thus, most school teachers need further educational NOS experiences and instruction.
Andrea Rae Milner   +2 more
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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