Results 41 to 50 of about 149,771 (261)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Distinguishing implicit and explicit learning [PDF]

Psychonomic Bulletin & Review, 1997
I agree with Dienes and Berry’s (1997) and Neal and Hesketh’s (1997) call for investigations of the qualitative differences between implicit and explicit learning and note that such investigations must be guided by a workable definition of what is implicit and by theories that predict what the qualitative differences might be.
openaire   +1 more source

Towards an explicit account of implicit learning [PDF]

Current Opinion in Neurology, 2005
The human brain supports acquisition mechanisms that can extract structural regularities implicitly from experience without the induction of an explicit model. Reber defined the process by which an individual comes to respond appropriately to the statistical structure of the input ensemble as implicit learning. He argued that the capacity to generalize
Forkstam, C., Petersson, K.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Working Memory Capacity Limits Motor Learning When Implementing Multiple Instructions

Frontiers in Psychology, 2017
Although it is generally accepted that certain practice conditions can place large demands on working memory (WM) when performing and learning a motor skill, the influence that WM capacity has on the acquisition of motor skills remains unsubstantiated ...
Tim Buszard, Tim Buszard, Damian Farrow, Damian Farrow, Simone J. J. M. Verswijveren, Simone J. J. M. Verswijveren, Machar Reid, Machar Reid, Jacqueline Williams, Remco Polman, Remco Polman, Fiona Chun Man Ling, Fiona Chun Man Ling, Rich S. W. Masters, Rich S. W. Masters   +14 more
doaj   +1 more source

Multidisciplinary Views on Applying Explicit and Implicit Motor Learning in Practice: An International Survey. [PDF]

PLoS ONE, 2015
A variety of options and techniques for causing implicit and explicit motor learning have been described in the literature. The aim of the current paper was to provide clearer guidance for practitioners on how to apply motor learning in practice by ...
Melanie Kleynen, Susy M Braun, Sascha M C Rasquin, Michel H C Bleijlevens, Monique A S Lexis, Jos Halfens, Mark R Wilson, Rich S W Masters, Anna J Beurskens   +8 more
doaj   +1 more source

The Emergence of Explicit Memory during Learning [PDF]

Cerebral Cortex, 2010
In incidental learning situations, contingencies are extracted from the environment without the intention to learn and can change behavior without awareness for the extracted regularity. The development of explicit access to the learned regularity is an important learning mechanism that is rarely examined.
Michael, Rose, Hilde, Haider, Christian, Büchel   +2 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pemahaman Konsep Matematis Siswa Sekolah Menengah Pertama: Pengaruh Explicit Instruction Ditinjau dari Self-Reliance

Arithmetic, 2023
The purpose of this study was to determine the effect of the explicit instruction learning model on the understanding of mathematical concepts in terms of self-reliance of junior high school students.
Jeni Safitri, Bambang Sri Anggoro, Abi Fadila, Wahyu Nofiansyah   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source