Results 61 to 70 of about 90,821 (258)
A memória e o impacto do trauma numa perspectiva desenvolvimental.
Acta Médica Portuguesa, 2010 The purpose of this article is to review the main neuroanatomic structures and the neurotransmission process involved at memory. Memory is dynamic based on the reunion of aspects of neuronal activation, in a process based on the individual experiences ...
Maria Moura, José Estrada
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Effects of Divided Attention at Retrieval on Conceptual Implicit Memory
Frontiers in Psychology, 2016 This study investigated whether conceptual implicit memory is sensitive to process-specific interference at the time of retrieval. Participants performed the implicit memory test of category exemplar generation (Experiments 1 and 3), or the matched ...
Matthew W. Prull +3 more
doaj +1 more source
Explicit mentalizing mechanisms and their adaptive role in memory conformity. [PDF]
PLoS ONE, 2013 Memory conformity occurs when an individual endorses what other individuals remember about past events. Research on memory conformity is currently dominated by a 'forensic' perspective, which views the phenomenon as inherently undesirable.
Rebecca Wheeler +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Psicologia: Reflexão e Crítica, 2008 This article presents a review of the literature about memory development, organized according to the different storages or memory systems. The development in sensory memory, working memory, explicit memory and implicit memory is analysed from the ...
Maria Paula Carneiro
doaj
Explicit memory in Schizophrenia
European Psychiatry, 2011 ObjectiveStudy of explicit memory of schizophrenic patients. Compared with control subjects.Methodsn = 21:-Schizophrenia Group (GE): 14 patients diagnosed with schizophrenia (DSM-IV criteria)-Control Group (CG): 7 subjects with no psychiatric diagnosis.Data analysis:-Analysis of variance for comparison between groups-Contrast-Test Means for intragroup ...
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source