Results 1 to 10 of about 127,128 (302)

Efficient and Stable Time Integration of Cahn–Hilliard Equations: Explicit, Implicit, and Explicit Iterative Schemes

Computational Mathematics and Mathematical Physics
The article proposes a new algorithm for numerical integration over time of the Cahn-Hilliard equation, based on the combined application of the Eyre splitting method and the local iteration modified (LIM) scheme for solving a finite-dimensional problem at each time step.
M. A. Botchev, I. A. Fahurdinov, Evgeny B. Savenkov   +2 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Large‐step explicit time integration via mass matrix tailoring

International Journal for Numerical Methods in Engineering, 2019
SummaryA method for tailoring mass matrices that allows large time‐step explicit transient analysis is presented. It is shown that the accuracy of the present tailored mass matrix preserves the low‐frequency contents while effectively replacing the unwanted higher mesh frequencies by a user‐desired cutoff frequency.
José A. González, K. C. Park
openaire   +4 more sources

An iterative dynamic chemical stiffness removal method for reacting flow simulations

Propulsion and Energy
An iterative dynamic chemical stiffness removal method (IDCSR) based on quasi-steady-state approximation (QSSA) is proposed. The IDCSR method is built on a previously developed non-iterative method which has proved to work well for small timestep sizes ...
Chao Xu, Tianfeng Lu
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A class of new nonlinear dynamic integral inequalities containing integration on infinite interval on time scales

Advances in Difference Equations, 2019
In this paper, we investigate some new nonlinear dynamic integral inequalities containing integration on infinite interval on time scales, which provide explicit bounds on unknown functions.
Haidong Liu, Cuiyuan Li, Feichao Shen
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

High-Order Time-Integration Schemes with Explicit Time-Splitting Methods

Monthly Weather Review, 2009
Abstract New high-order time-integration schemes for fully elastic models are presented. The new schemes, formulated using the Richardson extrapolation that employs leapfrog-type schemes, can give a good performance for linear model problems and ensure overall stability when they are combined with a forward–backward scheme for fast waves.
Tae-Young Lee, Sang-Hun Park
openaire   +1 more source