Results 171 to 180 of about 127,128 (302)
Explicit time integration of the Navier-Stokes equations using the local iteration method
, 2019 : New time integration algorithm LI-M is proposed for the Navier-Stokes equations of compressible heat-conducting flows. This algorithm is based on the splitting procedure by convection and diffusion processes over a time step.
Zhukov V.T. http://library.keldysh.ru/author_page.asp?aid=1174 +3 more
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Beyond Integration: Unresolved Causal and Temporal Challenges in Multi-Domain QT Risk Modeling. [PDF]
Clin CardiolMudasir M, Rafiq S.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
How to Design and Implement a Structured Curriculum in Health Professions Education: A Nine-Step Framework Building on Kern's Approach. [PDF]
Clin TeachEscourrou É, Oustric S.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Explicit time integration with large time steps for the heat flow equations
, 2012 We present a novel fully explicit time integration method that remains stable for large time steps, requires neither matrix inversions nor solving a system of equations and therefore allows for nearly effort-less parallelization. In this first paper the proposed approach is applied to solve conduction heat transfer problems, showing that it is stable ...
Becker, P., Nigro, N., Idelsohn, S.
openaire +1 more source
Why health recommender systems struggle to reach clinical practice: A lifecycle-oriented systematic review. [PDF]
iScienceEl Miayar O, Berrado A.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
My avatar moves with me, so I am the one acting: Avatar responsiveness supports implicit sense of agency in virtual reality. [PDF]
PLoS OneMariano M +8 more
europepmc +1 more source