Results 131 to 140 of about 1,736,331 (317)

The journal of Egyptian archaeology.

open access: yes, 1914
Some no. issued combined.Supplements accompany some vols.Mode of access: Internet.Vols. for 1921- issued by: Egypt Exploration Society.Vols. 1 (1914)-20 (1934). 1 v.; v. 21 (1935)-40 (1954).
Egypt Exploration Fund.   +1 more
core  

Stimulating Exploration in Complex Task Learning via Pre-Practice and Intermittent Knowledge Enrichment [PDF]

open access: yes, 2019
A growing body of scholarly literature points to the importance of exploratory behavior in the acquisition of complex skills. The purpose of this laboratory study, in which 257 undergraduate students (64% male) learned to play a complex video game, was ...
Westlin, Joseph
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Pressure Suit Vacuum Chamber Testing

open access: yes
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Petersen, Eric   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Living Inside the UA Space Analog

open access: yes
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Hand Grip Strength Demonstration Inside Full Pressure Suit

open access: yes
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core  

Tales of serial exploration [PDF]

open access: yes
In this paper, we examine the firm and ecological factors that affect the long-term sustainability of exploration. We analysed the investment decisions by US venture capital firms to enter new technological domains over a 43-year period.
PABLO MARTIN
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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