Results 51 to 60 of about 140,450 (312)

Modern mechanisms make manless Martian mission mobile: Spin-off spells stairclimbing self-sufficiency for earthbound handicapped [PDF]

open access: yes, 1975
Concepts were developed for three wheel chairs from progressively improving designs of a proposed unmanned roving vehicle for the surface exploration of Mars; as a spin-off, a concept for a stair-climbing wheel chair was generated.
Hassel, D. R.   +2 more
core   +1 more source

Human crew-related aspects for astrobiology research [PDF]

open access: yes, 2011
Several space agencies and exploration stakeholders have a strong interest in obtaining information on technical and human aspects to prepare for future extra-terrestrial planetary exploration.
Foing, B.H., Pletser, V., Thiel, C.S.
core   +2 more sources

Progress of radio occultation exploration of Mars

open access: yes地球与行星物理论评
Mars is the sister star of Earth. Studying Mars is important to understand its evolution as well as that of Earth and even the solar system. Since the launch of American Mariner 4 in 1964 and the first successful use of radio occultation technology to ...
Luo Xiao   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Muon radiography for exploration of Mars geology [PDF]

open access: yesGeoscientific Instrumentation, Methods and Data Systems, 2013
Muon radiography is a technique that uses naturally occurring showers of muons (penetrating particles generated by cosmic rays) to image the interior of large-scale geological structures in much the same way as standard X-ray radiography is used to image
S. Kedar   +5 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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