Results 71 to 80 of about 17,950 (315)

Immunological detection of small organic molecules in the presence of perchlorates: relevance to the life marker chip and life detection on Mars. [PDF]

, 2011
The proposed ExoMars mission, due to launch in 2018, aims to look for evidence of extant and extinct life in martian rocks and regolith. Previous attempts to detect organic molecules of biological or abiotic origin on Mars have been unsuccessful ...
David C. Cullen, Sims, Mark R., Cullen, David C., Rix, Catherine S., Catherine S. Rix, Mark R. Sims   +5 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Understanding the CO2 Scrubber Used at the Space Analog for the Moon and Mars

, 2023
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Perspectives for Crewed Missions to Mars: Exploration from Orbit and/or Short Stay

The debate “humans versus robots”, on Mars or anywhere else will not be engaged here. The decision has been made—by a single entity, a coalition, or a wide international agreement—to send astronauts to Mars.
Puumala, Mikko, de Vera, Jean Pierre Paul, Sivula, Oskari, Kereszturi, Akos, Milligan, Tony, Ewald, Reinhold, Mason, Nigel, Javaux, Emmanuelle J., Possnig, Carmen, Viso, Michel, Chatzitheodoridis, Elias, Lee, Natuschka M.,, Siljeström, Sandra, De Vera, Jean-Pierre, Javaux, Emmanuelle, Arnould, Jacques, Holynska, Malgorzata, Detrell, Gisela, Freissinet, Caroline, Vago, Jorge L., Mason, N. J., Lehto, Kirsi, Lee, Natuschka M., Lee, Natuschka   +23 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Getting Started in Mars Exploration [PDF]

This is an introduction in a series of activities on Mars that use images as integral parts of the lesson. Students are introduced to the images and begin a Mars journal. The purpose is to probe students' understanding of Mars to give the teacher a sense

core   +1 more source

Novel solvent systems for in situ extraterrestrial sample analysis [PDF]

, 2010
The life marker chip (LMC) is being designed to test for the chemical signature of life in the soil and rocks of Mars. It will use an antibody array as part of its detection and characterisation system and aims to detect both polar and non-polar ...
Baki, Alexander O., Mark A. Sephton, Court, Richard W., Sims, Mark R., Cullen, David C., Sephton, Mark A., Richard W. Court, Alexander O. Baki, Mark R. Sims, David Cullen   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source