Results 91 to 100 of about 17,950 (315)

Extraterrestrial Mossbauer spectroscopy: more than 3 years of Mars exploration and developments for future missions

, 2008
After almost 4 years of operating on the surface of Mars, Mössbauer spectroscopy has become a mature technique for robotic planetary exploration.
Morris, Richard Van, Fleischer, Iris, Schröder, Christian, Rodionov, Daniel S, Klingelhoefer, Goestar, Blumers, Mathias   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Biosignatures on Mars: What, Where, and How? Implications for the Search for Martian Life

, 2015
International audienceThe search for traces of life is one of the principal objectives of Mars exploration. Central to this objective is theconcept of habitability, the set of conditions that allows the appearance of life and successful establishment ...
Bost, Nicolas, Gautret, P, Bréhéret, Jean-Gabriel, Gaboyer, F, Loizeau, Damien, Bost, N, Westall, Frances, Gautret, Pascale, Cockell, Charles S., Bertrand, Marylène, Foucher, Frédéric, Gaboyer, Frédéric, Campbell, Kathleen, Kminek, Gerhard, Bertrand, M, Kminek, G, Westall, F, Loizeau, D, Vago, Jorge L., Foucher, F, Bréhéret, J-G, Cockell, CS, Campbell, Kathleen A., Vago, JL   +23 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Mars Human Exploration Objectives

, 1998
This paper reviews the objectives and other considerations of Human exploration of Mars. The objectives of human exploration of Mars are: (1) to learn how Mars is similar to, and different from, Earth; (2) to explore possible life, past and present; (3 ...
Briggs, Geoff
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

EXPANDING NASA FUNCTIONALITY USING ITS API AND IMPROVING INTEREST AMONG PEOPLE IN SPACE EXPLORATION

Автоматизация технологических и бизнес-процессов
. This scientific work focuses on developing a website aimed at expanding the functionality of NASA’s API and increasing public interest in space exploration.
Y. V. Popov, K. O. Kirei
doaj   +1 more source

Mars in Science Fiction and Our Perceptions of the Red Planet

Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration.
Lehoucq, Roland, Lee, Natuschka M.,, Dunér, David, Nováková, Julie Nekola, Carré, Fabrice, Persson, Erik, Lehto, Kirsi, Lee, Natuschka M.   +7 more
core   +1 more source

Human crew-related aspects for astrobiology research [PDF]

, 2011
Several space agencies and exploration stakeholders have a strong interest in obtaining information on technical and human aspects to prepare for future extra-terrestrial planetary exploration.
Foing, B.H., Vladimir Pletser, Thiel, C.S., Cora S. Thiel, Pletser, V., Bernard Foing   +5 more
core   +1 more source