Results 91 to 100 of about 166,259,392 (287)

Presentation: Curiosity’s First Year of Exploration on Mars

open access: yes, 2016
NASA’s second rover named “Opportunity” produced dramatic evidence that long ago, at least one area of Mars stayed wet for an extended period, suggesting that conditions could have been suitable for sustaining microbial life.
Grotzinger, John   +1 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

EXPANDING NASA FUNCTIONALITY USING ITS API AND IMPROVING INTEREST AMONG PEOPLE IN SPACE EXPLORATION

open access: yesАвтоматизация технологических и бизнес-процессов
. This scientific work focuses on developing a website aimed at expanding the functionality of NASA’s API and increasing public interest in space exploration.
Y. V. Popov, K. O. Kirei
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mars Human Exploration Objectives [PDF]

open access: yes, 1998
This paper reviews the objectives and other considerations of Human exploration of Mars. The objectives of human exploration of Mars are: (1) to learn how Mars is similar to, and different from, Earth; (2) to explore possible life, past and present; (3 ...
Briggs, Geoff
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Future robotic exploration using honeybee search strategy: Example search for caves on Mars [PDF]

open access: yes, 2011
Autonomous control has an increasing role in Earth and Space based applications. High level autonomy can greatly improve planetary exploration and is, in many cases, essential.
Kisdi, Áron   +3 more
core   +1 more source

A Review of Environmental Challenges Facing Martian Colonisation and the Potential for Terrestrial Microbes to Transform a Toxic Extraterrestrial Environment

open access: yesChallenges
Mars is a focus of New Space Age exploration and colonisation, but there are significant challenges to successful colonisation by humankind.
Daniel Keaney, Brigid Lucey, Karen Finn
doaj   +1 more source

Astrobiological Field Campaign to a Volcanosedimentary Mars Analogue Methane Producing Subsurface Protected Ecosystem: Imuruk Lake (Alaska)

open access: yesAdvances in Astronomy, 2011
Viking missions reported adverse conditions for life in Mars surface. High hydrogen signal obtained by Mars orbiters has increased the interest in subsurface prospection as putative protected Mars environment with life potential. Permafrost has attracted
F. Gómez   +9 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

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