Results 111 to 120 of about 17,950 (315)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Mars exploration on the move [PDF]

National Science Review, 2020
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Measuring the Elemental Composition of Phobos: The Mars‐moon Exploration with GAmma rays and NEutrons (MEGANE) Investigation for the Martian Moons eXploration (MMX) Mission

Earth and Space Science, 2019
The Mars‐moon Exploration with GAmma rays and NEutrons (MEGANE) investigation will use gamma‐ray and neutron spectroscopy to measure the elemental composition of Mars' moon Phobos.
David J. Lawrence, Patrick N. Peplowski, Andrew W. Beck, Morgan T. Burks, Nancy L. Chabot, Michael J. Cully, Richard C. Elphic, Carolyn M. Ernst, Samuel Fix, John O. Goldsten, Erin M. Hoffer, Hiroki Kusano, Scott L. Murchie, Brian C. Schratz, Tomohiro Usui, Zachary W. Yokley   +15 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Mars Historical and Ethical Context : Past, Present, and Imagination

Mars has long been a source of inspiration, imagination and, lately, aspiration for many. It has generated a breadth of beliefs and ideas, as well as hope for a bright future there.
Capova, Klara-Anna, Puumala, Mikko, Tønnessen, Morten, Sivula, Oskari, Tönnessen, Morten, Milligan, Tony, Lee, Natuschka M.,, Arnould, Jacques, Dunér, David, Ditrych, Ondřej, Schmidt, Nikola, Persson, Erik, Lee, Natuschka M.   +12 more
core   +1 more source

Inflatable structures for Mars Base 10

, 2012
A permanent manned settlement on the Martian surface requires the use of advanced technology concepts in order to become technically and financially feasible.
Sinn, Thomas, Thomas Sinn, Doule, Ondrej, Ondrej Doule   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Research on the Detection Method of Martian Atmospheric Temperature and Pressure Profile Based on Laser Occultation Technology

Remote Sensing
As an important target of space exploration, Mars has attracted a lot of attention due to its unique geographical and atmospheric conditions. The detection of the vertical profiles of Mars atmospheric parameters provides deeper insights into the ...
Ye Liu, Wei Kong, Xue Shen, Tao Chen, Genghua Huang   +4 more
doaj   +1 more source

Atmospheric origins of perchlorate on Mars and in the Atacama

, 2010
Times Cited: 22Isotopic studies indicate that natural perchlorate is produced on Earth in arid environments by the oxidation of chlorine species through pathways involving ozone or its photochemical products.
Claire, Mark, Clark, B. C., Hecht, M. H., Zahnle, K. J., Catling, D. C., Claire, M. W., Kounaves, S., Quinn, R. C.   +7 more
core   +1 more source