Results 101 to 110 of about 17,950 (315)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Low-cost, multi-agent systems for planetary surface exploration

, 2012
The use of off-the-shelf consumer electronics combined with top-down design methodologies have made small and inexpensive satellites, such as CubeSats, emerge as viable, low-cost and attractive space-based platforms that enable a range of new and ...
Punzo, Giuliano, Macdonald, Malcolm, Dobie, Gordon, Jamieson, Jonathan, Bennet, Derek James   +4 more
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Rapid prototyping for Martian space systems [PDF]

, 2022
With the clear path towards Mars for future human exploration missions, rapid prototyping tools may enhance different missions' architectural solutions.
Giuseppe Governale, Giuseppe Narducci, Jasmine Rimani, Roberta Fusaro, Nicole Viola   +4 more
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Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A Review of Environmental Challenges Facing Martian Colonisation and the Potential for Terrestrial Microbes to Transform a Toxic Extraterrestrial Environment

Challenges
Mars is a focus of New Space Age exploration and colonisation, but there are significant challenges to successful colonisation by humankind.
Daniel Keaney, Brigid Lucey, Karen Finn
doaj   +1 more source

ELECTROMAGNETIC PROPAGATION MODELLING FOR GPR EXPLORATION OF MARTIAN SUBSOIL

, 2003
The use of GPR for Mars exploration has been suggested by several authors in the past ten years. Some of the instruments proposed in the late 90s were designed to investigate the subsurface at great depth (thousands of meters) and therefore implemented a
A. GALLI, GALLI, Alessandro, PETTINELLI, Elena, A. R. PISANI, D. DEL VENTO AND A. CERETI, A. Cereti, BURGHIGNOLI, Paolo, P. BURGHIGNOLI, F. TICCONI, E. Pettinelli, D. Del Vento   +10 more
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Mineralogy and chemistry of cobbles at Meridiani Planum, Mars, investigated by the Mars Exploration Rover Opportunity [PDF]

, 2010
Numerous loose rocks with dimensions of a few centimeters to tens of centimeters and with no obvious physical relationship to outcrop rocks have been observed along the traverse of the Mars Exploration Rover Opportunity.
Morris, Richard Van, Squyres, Steven W, Fleischer, Iris, Weitz, C., Brueckner, Johannes, Morris, R. V., Klingelhöfer, G., I. Fleischer, C. Weitz, Golombek, M., D. Mittlefehldt, Brückner, J., Gellert, Ralf, Gellert, R., Johnson, J. R., Weitz, Catherine, Klingelhoefer, Goestar, Mittlefehldt, David W, M. Golombek, Ashley, J., J. Brückner, Golombek, Matthew, Jolliff, B., Ashley, James W, J. R. Johnson, Mittlefehldt, D., Schröder, C., Herkenhoff, K., Jolliff, Bradley L, de Souza Jr, Paulo A, Cohen, B. A., B. Jolliff, Cohen, Barbara A, Farrand, William H, Fleischer, I., S. W. Squyres, G. Klingelhöfer, C. Schröder, Farrand, W., Treguier, Erwan, K. Herkenhoff, B. A. Cohen, W. Farrand, J. Ashley, Herkenhoff, Kenneth E, Tréguier, E., Schröder, Christian, R. Gellert, de Souza, P. A., Johnson, Jeffrey R, Squyres, S. W., E. Tréguier, R.V. Morris, P. A. de Souza   +53 more
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Astrobiological Field Campaign to a Volcanosedimentary Mars Analogue Methane Producing Subsurface Protected Ecosystem: Imuruk Lake (Alaska)

Advances in Astronomy, 2011
Viking missions reported adverse conditions for life in Mars surface. High hydrogen signal obtained by Mars orbiters has increased the interest in subsurface prospection as putative protected Mars environment with life potential. Permafrost has attracted
F. Gómez, O. Prieto-Ballesteros, D. Fernández-Remolar, J. A. Rodríguez-Manfredi, M. Fernández-Sampedro, M. Postigo Cacho, J. Torres Redondo, N. Rodríguez, J. Gómez-Elvira, R. Amils   +9 more
doaj   +1 more source

Mars Science Laboratory: The Next Rover

, 2008
This presentation was part of the session : Opening - Thursday Parallel Sessions - June 26Sixth International Planetary Probe WorkshopThe Mars Science Laboratory rover represents firsts in many aspects for interplanetary exploration.
Meyer, Michael D.
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