Results 131 to 140 of about 17,950 (315)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Mars Exploration Rovers: 4 Years on Mars

, 2008
This January, the Mars Exploration Rovers "Spirit" and "Opportunity" are starting their fifth year of exploring the surface of Mars, well over ten times their nominal 90-day design lifetime.
Landis, Geoffrey A.
core  

Selecting the geology filter wavelengths for the ExoMars Panoramic Camera instrument

, 2012
The Panoramic Camera (PanCam) instrument will provide surface remote sensing data for the ExoMars mission. A combination of wide-angle stereo, multispectral, and high resolution imagery will generate contextual geological information to help inform which
Davis, Lottie E., Prosser, Bryan J., Cousins, Claire R., Barnes, Dave, Coates, AJ, Gunn, Matthew, Gunn, M., Gunn, M, Coates, Andrew, Cousins, CR, Barnes, D.P., Barnes, Dave P., Prosser, B.J., Barnes, DP, Prosser, Bryan, Griffiths, AD, Crawford, Ian A., Griffiths, Andrew, Davis, L.E., Davis, LE, Coates, Andrew J., Crawford, IA, Griffiths, Andrew D., Cousins, Claire Rachel, Davis, Lottie, Prosser, BJ, Crawford, Ian   +26 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Supporting the Vision: Alta’s Activities and Capabilities for Mars Exploration

, 2009
The feasibility of affordable Mars exploration scenarios within a reasonably short time frame is crucially dependent on the capability to effectively cope with a number of key technology issues as well as with the availability of adequate skills and ...
ANDRENUCCI, MARIANO, MARCUCCIO, SALVO
core  

Towards Permanent Settlements on Mars (from 1000 to 100,000 People)

If early crewed outposts on Mars can develop adequate habitats and in-situ resource utilization capabilities, they may evolve into small permanent settlements.
Krassakis, Alexandros, Hedlund, Maria, Gross, Christoph, Hofmann, Mahulena, Ditrych, Ondrej, Rückert, Patrick, Schmidt, Nikola, Detrell, Gisela, Meneghin, Andrea, Cesari, Laetitia, Lehto, Kirsi, Puumala, Mikko, Clerc, Philippe, Sivula, Oskari, Tönnessen, Morten, Kereszturi, Akos, Poulet, Lucie, Brucato, John Robert, Fornaro, Teresa, Mason, Nigel, Possnig, Carmen, Tracht, Kirsten, Chatzitheodoridis, Elias, Lee, Natuschka M.,, Noack, Lena, Selke, Stefan, Tikkanen, Mikko, Persson, Erik, Goncalves, Barbara   +28 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source