Results 91 to 100 of about 10,775,671 (299)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Groundwater potential mapping in semi-arid region of Northern Nigeria by integrating analytic hierarchy process and GIS

Frontiers in Water
Groundwater resource management in drylands, characterized by climate variability and population growth, is difficult. Exploration and exploitation of groundwater, due to inadequate surface water is very costly. This study employed the analytic hierarchy
Abdulmutallib A. Saidu, Ali Aldrees, Salisu Dan'azumi, Sani I. Abba, Salahu M. Hamza   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Exploring the Potential Treatment for Mpox.

Acta medica Indonesiana
Monkeypox (Mpox) is a virus that originally infected only animals. Caused by the monkeypox virus, this infection presents with symptoms similar to smallpox. Although two years have passed since the 2022 outbreak, new cases continue to emerge monthly. Initially, human cases of mpox were confined to outbreaks in central and western Africa.
Kevin Kevin, Robert Sinto, Leonard Nainggolan, Adeline Pasaribu, Sharifah Shakinah, Khie Chen Lie   +5 more
openaire   +3 more sources

Exploration of the Potential of Soil Yeasts for their Plant Growth-Promoting Traits

Journal of Pure and Applied Microbiology
Soil microorganisms, as the sole component, play a major role in nurturing agricultural productivity and regulating soil health by affecting biological and biochemical processes and soil functioning.
R. Parimala Devi, P. Yamunasri, K. Senthilraja, D. Balachandar, D. Udhaya Nandhini, S. Venkatesan, D. Ramesh   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

FS8 IVA Suit Glove Touch Screen Capabilities Verified

Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Homer, Peter, Tresch, Trent
core   +1 more source

Deep potential-driven structure exploration of ice polymorphs

The Innovation
Ice, a ubiquitous substance in nature, exhibits diverse forms under varying temperature and pressure conditions. However, our understanding of ice polymorphs remains incomplete.
Yuefeng Lei, Xiangyang Liu, Yaochen Yu, Haiyang Niu   +3 more
doaj   +1 more source