Results 101 to 110 of about 10,775,671 (299)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Exploration of Anticancer and Antibacterial Potential of Non-cytotoxic Moringa oleifera Leaf Extract

Journal of Pure and Applied Microbiology
To characterize the phytoconstituents and explore the antibacterial efficacy, cytotoxicity of Moringa oleifera leaf extract, assessing its potential as natural therapeutic alternative for antimicrobial and anticancer applications. Moringa oleifera leaves
Snehashish Modak, Tamanna Aktar, Aditi Bhattacharya, Debjani Bhowmik, Dipankar Das, Shukdeb Acharjee, Abhijit Bhattacharya, Debasish Maiti, Manash C. Das   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Research progress and potential directions of oil and gas exploration in key fields of Junggar Basin

Youqi dizhi yu caishoulu
Shengli exploration area in Junggar Basin is mainly located in the ultra-denudation zone， complex piedmont zone， and deep subsag zone around the basin. The conditions for oil and gas accumulation are complex， and exploration is difficult.
WANG Jinduo, ZHANG Guanlong, ZHUANG Xinming, GONG Yajun, ZHANG Yi, QU Yansheng, XUE Yan, CHENG Shiwei   +7 more
doaj   +1 more source

High Altitude Skydiving Apparatus

, 2022
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Exploration situation and development strategy of Shengli Oilfield during “14th Five-Year Plan in 2021-2025 ”

Youqi dizhi yu caishoulu
After more than 60 years of exploration and development， the conventional oil and gas in the middle and shallow layers of the oil-rich sag in Jiyang Depression and in the ultra-denudation zones at the western edge of Junggar Basin have been in the mature
LIU Huimin
doaj   +1 more source