Results 171 to 180 of about 960,650 (292)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice. [PDF]

Pain, 2021
Burek DJ, Massaly N, Doering M, Zec A, Gaelen J, Morón JA.   +5 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Editorial: Vagrancy, exploratory behavior and colonization by birds: Escape from extinction?

Frontiers in Ecology and Evolution, 2022
Richard Reed Veit, Richard Reed Veit, Lisa Louise Manne, Lisa Louise Manne, Lucinda C. Zawadzki, Marlen Acosta Alamo, Marlen Acosta Alamo, Robert William Henry   +7 more
doaj   +1 more source

Sex-specific associations of the maturation locus vgll3 with exploratory behavior and boldness in Atlantic salmon juveniles. [PDF]

Ecol Evol
Bangura PB, Tiira K, Aykanat T, Niemelä PT, Erkinaro J, Liljeström P, Toikkanen A, Primmer CR.   +7 more
europepmc   +1 more source

When Collaborating in Constructive Task With Spouse: Attachment Orientation Predicts Exploratory Behavior Among Older Couples. [PDF]

Front Psychol, 2021
Wang Y, Cao X, Li F, Wang D.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Exploratory behavior is associated with the cognitive speed in male chestnut thrushes. [PDF]

Curr Zool
Lou Y, Zou Y, Fang Y, Sun Y.
europepmc   +1 more source

Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster). [PDF]

Psychopharmacology (Berl), 2021
Simmons TC, Singh ALK, Bales KL.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source