Results 171 to 180 of about 968,662 (293)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice. [PDF]

Pain, 2021
Burek DJ, Massaly N, Doering M, Zec A, Gaelen J, Morón JA.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Sex-specific associations of the maturation locus vgll3 with exploratory behavior and boldness in Atlantic salmon juveniles. [PDF]

Ecol Evol
Bangura PB, Tiira K, Aykanat T, Niemelä PT, Erkinaro J, Liljeström P, Toikkanen A, Primmer CR.   +7 more
europepmc   +1 more source

When Collaborating in Constructive Task With Spouse: Attachment Orientation Predicts Exploratory Behavior Among Older Couples. [PDF]

Front Psychol, 2021
Wang Y, Cao X, Li F, Wang D.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Exploratory behavior is associated with the cognitive speed in male chestnut thrushes. [PDF]

Curr Zool
Lou Y, Zou Y, Fang Y, Sun Y.
europepmc   +1 more source

Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster). [PDF]

Psychopharmacology (Berl), 2021
Simmons TC, Singh ALK, Bales KL.
europepmc   +1 more source

Editorial: Vagrancy, exploratory behavior and colonization by birds: Escape from extinction?

Frontiers in Ecology and Evolution, 2022
Richard Reed Veit, Richard Reed Veit, Lisa Louise Manne, Lisa Louise Manne, Lucinda C. Zawadzki, Marlen Acosta Alamo, Marlen Acosta Alamo, Robert William Henry   +7 more
doaj   +1 more source