Results 41 to 50 of about 265,067 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Persian Mentalized Affectivity Scale (MAS): Reliability, Validity, and Cultural Considerations

Brain and Behavior
Introduction Mentalization and emotion regulation are increasingly recognized as key factors in the development and persistence of psychological disorders.
Fateme Jafarpoor, Elmira Shayegh, Parvin Haghjoo, Saeed Ghanbari   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Computational algorithm based on health and lifestyle traits to categorize lifemetabotypes in the NUTRiMDEA cohort

Scientific Reports
Classifying individuals based on metabotypes and lifestyle phenotypes using exploratory factor analyses, cluster definition, and machine-learning algorithms is promising for precision chronic disease prevention and management.
Andrea Higuera-Gómez, Víctor de la O, Rodrigo San-Cristobal, Rosa Ribot-Rodríguez, Isabel Espinosa-Salinas, Alberto Dávalos, María P. Portillo, J. Alfredo Martínez   +7 more
doaj   +1 more source

Initial validation of scales measuring trust and attitudes toward (educational) science in Belgium

Frontiers in Education
IntroductionThis study is part of a broader effort to validate psychometric scales translated and adapted to the French-speaking Belgian teacher education context. It examines the factor structure and internal consistency of several instruments measuring
Eva Gonzalez-Vargas, Remy Decorte, Antoine Derobertmasure, Dylan Dachet   +3 more
doaj   +1 more source

Spirituality as a scientific construct: testing its universality across cultures and languages.

PLoS ONE, 2015
Using data obtained from 4004 participants across eight countries (Canada, India, Japan, Korea, Poland, Slovakia, Uganda, and the U.S.), the factorial reliability, validity and structural/measurement invariance of a 30-item version of Expressions of ...
Douglas A MacDonald, Harris L Friedman, Jacek Brewczynski, Daniel Holland, Kiran Kumar K Salagame, K Krishna Mohan, Zuzana Ondriasova Gubrij, Hye Wook Cheong   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Conflict Resolution Styles Scale in Romantic Relationship: The Validity and Reliability Study [PDF]

Nesne Psikoloji Dergisi, 2016
The aim of the current study is to test the reliability and validity of the 'Conflict Resolution Styles Scale' (CRSS), which was developed by the researchers. For this aim, two studies have been conducted.
Ayca Ozen, Selin Salman Engin, Nuray Sakalli Ugurlu   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source