Results 111 to 120 of about 304,850 (274)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Exploratory Factor Analysis: Conceptual and Methodological Basis

Revista Argentina de Ciencias del Comportamiento, 2010
The present work reviews the foundations and principal procedures of exploratory factor analysis conceived as an essential method for the construction, adjustment and validation of psychological tests.
Leonardo Medrano, Edgardo R. Pérez
doaj  

Investigating underlying factors of collaboration for construction projects in emerging economies using exploratory factor analysis

, 2019
Hazhar Faris, Mark Gaterell, David Hutchinson   +2 more
openalex   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Exploratory Factor Analysis Research Instrument Confidence Attitude Toward Students

, 2019
NoAli, Edi Istiyono, Supahar Supahar
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Development Study of Thoughts Scale Towards Measurement and Assessment Course in Higher Education

International Journal of Assessment Tools in Education, 2016
Considering that measurement and assessment, the most critical component of the education process, should be properly carried out by educators, it is necessary to make sure that education faculties deliver the measurement and assessment course ...
Serhat Süral
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exploratory Factor Analysis: Conceptual and Methodological Basis

Revista Argentina de Ciencias del Comportamiento, 2014
The present work reviews the foundations and principal procedures of exploratory factor analysis conceived as an essential method for the construction, adjustment and validation of psychological tests.
Pérez, Edgardo R., Medrano, Leonardo
doaj  

Exploratory Factor Analysis

, 2012
Factor analysis examines the inter-correlations that exist between a large number of items (questionnaire responses) and in doing so reduces the items into smaller groups, known as factors. These factors contain correlated variables and are typically quite similar in terms of content or meaning.
openaire   +1 more source