Results 121 to 130 of about 25,538,498 (274)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2019 Factor/pattern coefficients from exploratory factor analysis (EFA) and confirmatory factor analysis (CFA).
Prathiba Natesan (7224218) +3 more
core +1 more source
VALIDITY OF INSTRUMENT MEASURING SECONDARY SCHOOL STUDENTS LEARNING DIFFICULTIES IN PHYSIC EDUCATION
Jurnal Ilmiah Ilmu Terapan Universitas JambiIn learning physic, students might experience learning difficulties that could hinder the knowledge transfer and the efficiency of the learning. It's caused by a limited number of instruments that are valid to measure students' learning difficulty in ...
Mutahharah Hasyim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Exploratory factor analysis and confirmatory factor analysis for the YQOL-W three-factor model.
, 2014 Exploratory factor analysis and confirmatory factor analysis for the YQOL-W three-factor model.
Todd C. Edwards (636389) +5 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
مجله اپیدمیولوژی ایران, 2014 Background & Objectives : Leadership power and management are discussed as sensitive and key elements in the safety issue. A safety leader can provide the necessary incentives for hard work, efficiency, and more productivity in the organization which ...
SJ Tabibi +3 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Stressful Life Events in Iranian Adults Society: Identification and Redefinition of Dimensions
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Stressful life events can lead to psychological problems, heart disease, stroke, etc. Multidimensional nature of stress calls for advanced statistical methods that could evaluate these dimensions based on symptoms of stress ...
Sara Rezaei +6 more
doaj