Results 141 to 150 of about 341,973 (244)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort. [PDF]

BMC Public Health
Geravandi S, Emamgholipour S, Pakdaman M, Sari AA, Esmaeili A.   +4 more
europepmc   +1 more source

Psychometric properties of the Italian version of the staff attitude to coercion scale: an exploratory factor analysis. [PDF]

Front Psychiatry, 2023
Venturini P, Bassi G, Salcuni S, Kotzalidis GD, Telesforo CL, Salustri E, Trevisi M, Roselli V, Tarsitani L, Infante V, Niolu C, Polselli G, Boldrini T.   +12 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Exploratory factor analysis on the development and validation of the understanding, attitude, practice and health literacy questionnaire on COVID-19 in Malay language. [PDF]

Sci Rep
Dalawi I, Isa MR, Aimran N.
europepmc   +1 more source

Preventing and developmental factors of sustainability in healthcare organisations from the perspective of decision makers: an exploratory factor analysis. [PDF]

BMC Health Serv Res, 2023
Calabrese M, Suparaku S, Santovito S, Hysa X.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploring patterns of multimorbidity in South Korea using exploratory factor analysis and non negative matrix factorization. [PDF]

Sci Rep
Kim Y, Park S, Choi YM, Yoon BH, Kim SH, Park J, Oh HJ, Lim Y, Lee J, Park B.   +9 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Evaluating medical service performance of hospitals in Sichuan Province, China: exploratory factor analysis and hierarchical clustering analysis based on diagnosis-related groups. [PDF]

Front Public Health
Liu X, Cao J, Ge R, Jiang O.
europepmc   +1 more source