Results 171 to 180 of about 304,850 (274)

Exploratory factor analysis of constructs used for investigating research uptake for public healthcare practice and policy in a resource-limited setting, South Africa. [PDF]

BMC Health Serv Res, 2023
Sigudla J, Maritz JE.
europepmc   +1 more source

The Exploratory Factor Analysis of the Six Dimension of Parenting Scale in the Population of Chinese Academically Successful College Students

Ying Han
openalex   +1 more source

Erratum to: Factors influencing network risk judgments: a conceptual inquiry and exploratory analysis [PDF]

, 2015
Jennifer Cowley, Frank L. Greitzer, Bronwyn Woods   +2 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evaluating medical service performance of hospitals in Sichuan Province, China: exploratory factor analysis and hierarchical clustering analysis based on diagnosis-related groups. [PDF]

Front Public Health
Liu X, Cao J, Ge R, Jiang O.
europepmc   +1 more source

Preventing and developmental factors of sustainability in healthcare organisations from the perspective of decision makers: an exploratory factor analysis. [PDF]

BMC Health Serv Res, 2023
Calabrese M, Suparaku S, Santovito S, Hysa X.   +3 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Identifying the Gaps in Human Papillomavirus (HPV) Vaccine Uptake: An Exploratory Factor Analysis of Adults in Tennessee. [PDF]

Vaccines (Basel)
Cernasev A, Oyedeji O, Springer CM, Hagemann TM, Hohmeier KC, Kintziger KW.   +5 more
europepmc   +1 more source

Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire. [PDF]

Pak J Med Sci, 2023
Hussain SM, Zuberi BF, Rasheed T, Ali FS, Majid E.   +4 more
europepmc   +1 more source