Results 31 to 40 of about 6,762,219 (256)

Locomotor activity: A distinctive index in morphine self-administration in rats. [PDF]

, 2017
Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively ...
Qingyao Kong, Kong, Qingyao, Jian-Jun Zhang, Zhang, Jian-Jun, Kong Qingyao, Zhang Jian-Jun   +5 more
core   +1 more source

Anxiety-Like and Exploratory Behaviors of Isolation-Reared Mice in the Staircase Test

Journal of Pharmacological Sciences, 2007
The behavior of isolation-reared mice has not yet been studied in the staircase test. The present study examined the effects of anxiolytic or anxiogenic agents and isolation rearing on the behavior of ddY (outbred) strain mice in the staircase test ...
Yukio Ago, Keiko Takahashi, Shigeo Nakamura, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda   +5 more
doaj   +1 more source

Circadian Clock Protein Content and Daily Rhythm of Locomotor Activity Are Altered after Chronic Exposure to Lead in Rat

Frontiers in Behavioral Neuroscience, 2017
Lead exposure has been reported to produce many clinical features, including parkinsonism. However, its consequences on the circadian rhythms are still unknown.
Mariam Sabbar, Ouria Dkhissi-Benyahya, Abdelhamid Benazzouz, Abdelhamid Benazzouz, Nouria Lakhdar-Ghazal   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Defining a role for the peduncolopontine tegmental nucleus in striatal outflow [PDF]

, 2012
The pedunculopontine tegmental nucleus (PPTg) lies within the pontomesencephalon and contains cholinergic and non-cholinergic neurones. It has extensive afferent and efferent connections throughout the brain.
Allen, Laura F.
core   +1 more source

Профілактика порушень поведінкових реакцій щурів при застосуванні ноотропів з вальпроатом натрію

Medičnì Perspektivi, 2013
Using of anticonvulsants can trigger a number of side effects, such as possible changes in behavior and emotional state of people with epilepsy, risk of unwarranted aggression, nervousness, discoordination, sleepiness, encephalopathies.
A. V. Ivanov
doaj   +1 more source

Effect of Strychnine Sulfate on Locomotor Activity

, 1965
The effect of strychnine sulfate upon spontaneous locomotor activity in an open field was determined for 20 naive male Wistar rats. The experimental Ss were injected ip with 1.0 cc/kg of a 01% solution of strychnine sulfate in normal saline and the ...
George B. Kish, Robert G. Gibby, George C. Theologus   +2 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Comparison of exploratory activity in a non-social environment between control and PPA-treated groups.

, 2018
PPA-treated rats showed significantly reduced exploratory activity (A) and inner-square exploratory activity (B) during the whole PID period (days 0 to 14).
Yunho Jin (2123827), Seunghoon Lee (201604), Yunkyung Hong (4857166), Joo-Heon Kim (4857172), Jeonghyun Choi (4857169), Yonggeun Hong (4857175), Sang-Rae Lee (282186), Jinyoung Won (4857163), Tai-Young Hur (3833458)   +8 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source