Results 71 to 80 of about 176,958 (272)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comparing the ESEM and CFA approaches to analyze the Big Five factors [PDF]

Avaliação Psicológica, 2017
Marsh (2007) asserts that no self-reported questionnaire of the Big Five factors shows an acceptable degree of adjustment in confirmatory factor analyses (CFA).
Cristiano Mauro Assis Gomes, Jenny Gjikuria   +1 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Do homes that are more energy efficient consume less energy?: A structural equation model for England's residential sector [PDF]

, 2011
Energy consumption from the residential sector is a complex sociotechnical problem that can be explained using a combination of physical, demographic and behavioural characteristics of a dwelling and its occupants.
Kelly, S
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The construct validity of the Dutch personality inventory for DSM-5 personality disorders (PID-5) in a clinical sample [PDF]

, 2015
The factor structure and the convergent validity of the Personality Inventory for DSM-5 (PID-5), a self-report questionnaire designed to measure personality pathology as advocated in the fifth edition, Section III of Diagnostic and Statistical Manual of ...
Bastiaens, Tim, Claes, Laurence, Claes, Stephan, De Clercq, Barbara, De Fruyt, Filip, De Hert, Marc, Dirk, Smits, Lowyck, Benedicte, Rossi, Gina, Vanwalleghem, Dominique, Vermote, Rudi   +10 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Factor Structure and Psychometric Properties of Cognitive-Behavioral Scales in Caregivers of Persons with Dementia [PDF]

, 2018
Background/Purpose Caregiving can be costly to dementia caregivers\u27 well-being. Assessing the factor structure and psychometric properties of Cognitive-Behavioral Scales in dementia caregivers is an essential step in addressing the gap in the current ...
Bekhet, Abir K., Garnier-Villarreal, Mauricio   +1 more
core   +1 more source

Perfectionism and achievement goals in young Finnish ice-hockey players aspiring to make the Under-16 national team [PDF]

, 2009
Research on perfectionism suggests that is it useful to differentiate between perfectionistic strivings and perfectionistic concerns. Regarding the 2 x 2 achievement goal framework, the usefulness of this differentiation was recently demonstrated in a ...
Antony M. M., Arbuckle J. L., Brislin R. W., Byrne B. M., Cole D. A., Conroy D. E., Conroy D. E., Conroy D. E., Cronbach L. J., DiBartolo P. M., Dunkley D. M., Dunn J. G. H., Dunn J. G. H., Dunn J. G. H., Elliot A. J., Elliot A. J., Flett G. L., Flett G. L., Frost R. O., Frost R. O., Gould D., Gould D., Haase A. M., Hall H. K., Hall H. K., Hill A. P., Hoyle R. H., Joachim Stoeber, Jukka Tiikkaja, Kitsantas A., Kline R. B., Lemyre P.-N., Lundh L.-G., Lundh L.-G., McPherson S. L., Moller A. C., Nunnally J. C., Nunnally J. C., Oliver Stoll, Olli Salmi, Ommundsen Y., Pleva J., Rice K. G., Shafran R., Slade P. D., Spray C. M., Stoeber J., Stoeber J., Stoeber J., Stoeber J., Stumpf H., Stöber J., Tabachnick B. G., Terry-Short L. A., Vallance J. K. H.   +54 more
core   +1 more source