Results 101 to 110 of about 5,007,763 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

2005 AdvanceVT Work/Life Survey Questionnaire

, 2005
Virginia Tech is committed to maintaining a work environment in which all faculty members can succeed. In order to assist the university in achieving this goal, it is important to receive input from all faculty members at the university.
Virginia Tech. Center for Survey Research
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Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Lake Maurice, South Australia [cartographic material].

, 1942
1st ed. Relief shown by form lines and spot heights.; "This map is compiled from the latest Commonwealth and State information and is not the result of precise military survey"; "This map is an official document.
Australia. Army. Survey Corps.
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Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Oodnadatta, South Australia [cartographic material].

, 1941
1st ed. Shows telephone and power lines, electric power stations, roads, railways and aerodromes.; Relief shown by hachures and spot heights.; "This map is compiled from the latest Commonwealth and State information and is not the result of precise ...
Australia. Army. Survey Corps.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Ireland 1:250,000 series : [cartographic material] Ordnance Survey holiday map /

, 1980
Various eds. Tourist map series of Ireland showing international and county boundaries, roads, railways, water features, buildings and populated places.
Ordnance Survey (Ireland).
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Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Post-trial access to implantable neural devices: an exploratory international survey

BMJ Surgery, Interventions, & Health Technologies
Objectives Clinical trials of innovative neural implants are rapidly increasing and diversifying, but little is known about participants’ post-trial access to the device and ongoing clinical care.
Adrian Carter, Anna Wexler, Nathan Higgins, John Gardner, Philipp Kellmeyer, Kerry O'Brien   +5 more
doaj   +1 more source