Results 61 to 70 of about 638,033 (344)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Industry R&D needs in hydrogen safety

Applications in Energy and Combustion Science
Hydrogen's unique physicochemical and combustion properties make it stand out among fuels as new hydrogen production technologies, means of transportation, and consumers emerge.
Harri Kytömaa, Achim Wechsung, Georgios Dimitrakopoulos, Neil Cook, Daniel Jaimes, In Young Hur, Sahand Faraji   +6 more
doaj   +1 more source

Allometric Exponent and Randomness

, 2013
An allometric height-mass exponent $\gamma$ gives an approximative power-law relation $ \propto H^\gamma$ between the average mass $$ and the height $H$, for a sample of individuals.
Kim, Beom Jun, Minnhagen, Petter, Yi, Su Do   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cardiovascular safety of fixed-dose extended-release naltrexone/bupropion in clinical practiceKey takeaways

Obesity Pillars
Background: The fixed-dose extended-release combination of naltrexone/bupropion (NB-ER) is indicated to treat overweight and obesity in adults as an adjunct to a reduced-calorie diet and increased physical activity.
Michael Kyle, Dustin Burns, Catherine Rogers Murray, Heather Watson, Jeff Swaney, Samuel Spevack, Megan Leonhard, Michael Simon, Emma Moynihan, Kate L. Lapane, Shirley V. Wang, Craig L. Longo, Mary E. Ritchey, David D. Dore   +13 more
doaj   +1 more source

Can One Make Any Crash Prediction in Finance Using the Local Hurst Exponent Idea?

, 2003
We apply the Hurst exponent idea for investigation of DJIA index time-series data. The behavior of the local Hurst exponent prior to drastic changes in financial series signal is analyzed.
Ausloos, Ausloos, Baillie, Baillie, Baviera, Buldyrev, D Grech, De Lima, Ding, Fama, Granger, Ivanova, Liu, Lux, Mandelbrot, Muller, Pagan, Peng, Peng, Plerou, Stanley, Stanley, Vandewalle, Vandewalle, Z Mazur   +24 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Generalized Exponents and Forms [PDF]

Journal of Algebraic Combinatorics, 2005
Let \(V=\mathbb{C}^l\) or \(\mathbb{R}^l\) be a complex or real vector space. A reflection is an element of \(\text{GL}(V)\) whose fixed point set is a hyperplane in \(V\). Let \(G\) be a reflection group, i.e., a finite subgroup of \(\text{GL}(V)\) generated by reflections. We assume all \(G\)-modules are \(\mathbb{C} G\)-modules. For any \(G\)-module
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The minimum exponent of the primitive digraphs on the given number of arcs [PDF]

Opuscula Mathematica, 2004
Primitive digraphs on \(n\) vertices, \(k\) arcs and girth \(s\) are considered. By \(a(n,k,s)\) we mean the minimum exponent taken over all such digraphs. We estimate the number \(a(n,k,s)\) using the Frobenius number for special values of \(k\) and \(s\
Jolanta Rosiak
doaj