Results 61 to 70 of about 630,752 (343)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Industry R&D needs in hydrogen safety
Applications in Energy and Combustion ScienceHydrogen's unique physicochemical and combustion properties make it stand out among fuels as new hydrogen production technologies, means of transportation, and consumers emerge.
Harri Kytömaa +6 more
doaj +1 more source
Continuity Results and Estimates for the Lyapunov Exponent of Brownian Motion in Random Potential [PDF]
, 2014 We collect some applications of the variational formula established by Schr\"oder (1988) and Rue\ss (2013) for the quenched Lyapunov exponent of Brownian motion in stationary and ergodic nonnegative potential.
Rueß, Johannes
core
Probabilistic Fragmentation and Effective Power Law
, 1996 A simple fragmentation model is introduced and analysed. We show that, under very general conditions, an effective power law for the mass distribution arises with realistic exponent.
A. Hadas +8 more
core +1 more source
List decoding - Random coding exponents and expurgated exponents [PDF]
2014 IEEE International Symposium on Information Theory, 2014 28 pages; submitted to the IEEE Trans.
openaire +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Obesity PillarsBackground: The fixed-dose extended-release combination of naltrexone/bupropion (NB-ER) is indicated to treat overweight and obesity in adults as an adjunct to a reduced-calorie diet and increased physical activity.
Michael Kyle +13 more
doaj +1 more source
Expurgation Exponent of Leaked Information in Privacy Amplification for Binary Sources
, 2012 We investigate the privacy amplification problem in which Eve can observe the uniform binary source through a binary erasure channel (BEC) or a binary symmetric channel (BSC).
Watanabe, Shun
core +1 more source
Estimating Loynes’ exponent [PDF]
Queueing Systems, 2011 Loynes' distribution, which characterizes the one dimensional marginal of the stationary solution to Lindley's recursion, possesses an ultimately exponential tail for a large class of increment processes. If one can observe increments but does not know their probabilistic properties, what are the statistical limits of estimating the tail exponent of ...
Duffy, Ken R., Meyn, Sean P.
openaire +4 more sources
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source