Results 201 to 210 of about 396,375 (242)

The FleQ-FleN circuit balances flagellar number against fitness in <i>Pseudomonas aeruginosa</i>. [PDF]

open access: yesmBio
Migueles-Lozano A   +11 more
europepmc   +1 more source

Inverse Design of Pre‐Strain via a Predictive Electromechanical Model for Enhanced Strain Sensing

open access: yesAdvanced Science, EarlyView.
An analytical electromechanical model rooted in microcrack evolution mechanics is globally calibrated from only eight pre‐strain datasets, enabling prediction of the complete sensing response at untested pre‐strain values within the calibrated design space (R2 > 0.99).
Jia‐Chen Shang   +10 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem   +24 more
wiley   +1 more source

Functional Characterization of a De Novo <i>SCN2A</i> Mixed Variant Linked to Early Infantile Developmental and Epileptic Encephalopathy. [PDF]

open access: yesNeurol Genet
Corradi A   +16 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

open access: yesAdvanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song   +9 more
wiley   +1 more source

Self‐Sustaining Hybrid Passive Cooler Enabling Highly Effective Thermal Management for Outdoor Electronics

open access: yesAdvanced Science, EarlyView.
An innovative hybrid passive cooler integrates a porous radiative coating and an atmospheric moisture‐harvesting hydrogel within a melamine sponge skeleton, synergizing radiative cooling, sensible‐heat absorption, and latent‐heat evaporation. It maintains an average 8.3°C sub‐ambient cooling under sunlight and a maximum ∼42.4°C drop under 2000 W·m−2 ...
Qingyuan Du   +6 more
wiley   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

open access: yesAdvanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang   +9 more
wiley   +1 more source

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