Results 121 to 130 of about 42,170 (301)

Sufficient Statistics and Exponential Families

open access: yesThe Annals of Statistics, 1974
Using a locally Lipschitz function $T$ of $n > 1$ variables one can reduce data consisting of a sample of size $n$ to one real number. If we are given a family of probability measures on the real line which are equivalent to Lebesgue measure then $T$ yields a sufficient data reduction only if the given family is exponential.
openaire   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

open access: yesAdvanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green   +15 more
wiley   +1 more source

Gradient-free Hamiltonian Monte Carlo with Efficient Kernel Exponential\n Families [PDF]

open access: green, 2015
Heiko Strathmann   +4 more
openalex   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

A new theorem on exponential stability of periodic evolution families on Banach spaces

open access: yesElectronic Journal of Differential Equations, 2003
We consider a mild solution $v_f(cdot, 0)$ of a well-posed inhomogeneous Cauchy problem $dot v(t)=A(t)v(t)+f(t)$, $v(0)=0$ on a complex Banach space $X$, where $A(cdot)$ is a 1-periodic operator-valued function. We prove that if $v_f(cdot, 0)$ belongs to
Constantin Buse, Oprea Jitianu
doaj  

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

open access: yesAdvanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti   +13 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

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