Results 61 to 70 of about 565,015 (288)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Mathematical analysis of parameter maintenance in precision technological V and AC systems (rus) [PDF]

Инженерно-строительный журнал, 2011
Various industrial processes usually take place in the air and they require different parameters of air quality and accuracy of its maintenance.In present there are no rigorous analytical methods for reliable determination the actual accuracy of ...
Sotnikov A.G.
doaj  

On Transcendental Numbers

Axioms, 2014
Transcendental numbers play an important role in many areas of science. This paper contains a short survey on transcendental numbers and some relations among them.
Florin F. Nichita
doaj   +1 more source

The Process of Constructing Speed-time Function from Distance-Time Function y=2χ by Students Using Different Reasoning Methods for Continuous Change

Journal of Educational Research in Mathematics, 2021
This study investigates the way students perceive and express change in an exponential situation with different reasoning methods for continuous change - for example, students, who use chunky reasoning, construct a new function representing the change of
Donggun Lee
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Dual Taylor Series, Spline Based Function and Integral Approximation and Applications

Mathematical and Computational Applications, 2019
In this paper, function approximation is utilized to establish functional series approximations to integrals. The starting point is the definition of a dual Taylor series, which is a natural extension of a Taylor series, and spline based series ...
Roy M. Howard
doaj   +1 more source

Exponential Relationship Between Maximal Apnea Duration and Exercise Intensity in Non-apnea Trained Individuals

Frontiers in Physiology, 2022
It is well known that the duration of apnea is longer in static than in dynamic conditions, but the impact of exercise intensity on the apnea duration needs to be investigated.
Alexandre Guimard, Alexandre Guimard, Fabrice Joulia, Fabrice Joulia, Fabrice Prieur, Fabrice Prieur, Gauthier Poszalczyk, Gauthier Poszalczyk, Kader Helme, Kader Helme, François J. Lhuissier, François J. Lhuissier   +11 more
doaj   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

SINS/CNS/GNSS Integrated Navigation Based on an Improved Federated Sage–Husa Adaptive Filter

Sensors, 2019
Among the methods of the multi-source navigation filter, as a distributed method, the federated filter has a small calculation amount with Gaussian state noise, and it is easy to achieve global optimization.
Shuqing Xu, Haiyin Zhou, Jiongqi Wang, Zhangming He, Dayi Wang   +4 more
doaj   +1 more source