Results 51 to 60 of about 2,836,960 (293)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Exponential stability for linear evolutionary equations [PDF]

Asymptotic Analysis, 2013
We give an approach to exponential stability within the framework of evolutionary equations due to Picard [Math. Methods Appl. Sci. 32(14) (2009), 1768–1803]. We derive sufficient conditions for exponential stability in terms of the material law operator which is defined via an analytic and bounded operator-valued function and give an estimate for the ...
openaire   +3 more sources

Super-stability and stability of the exponential equations [PDF]

Journal of Mathematical Inequalities, 2010
In this paper, we introduce the concepts of super-stability, stability, δ -Ger-stability of the exponential equation of an operator from a normed space into a normed algebra. By using some results due to J. Baker and R. Ger, we obtain some new conclusions about these stabilities. Mathematics subject classification (2010): Primary 39B52, secondary 39B82,
Lu Xu, Huai-Xin Cao, Wen-Ting Zheng, Zhen-Xia Gao   +3 more
openaire   +1 more source

Sub-exponential stability for the beam equation

Journal of Differential Equations, 2023
We consider a one-parameter family of beam equations with Hamiltonian non-linearity in one space dimension under periodic boundary conditions. In a unified functional framework we study the long time evolution of initial data in two categories of differentiability: (i) a subspace of Sobolev regularity, (ii) a subspace of infinitely many differentiable ...
Roberto Feola, Jessica Elisa Massetti
openaire   +4 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

New Conditions for the Exponential Stability of Pseudolinear Difference Equations in Banach Spaces

Abstract and Applied Analysis, 2016
We study the local exponential stability of evolution difference systems with slowly varying coefficients and nonlinear perturbations. We establish the robustness of the exponential stability in infinite-dimensional Banach spaces, in the sense that the ...
Rigoberto Medina
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

New criteria for exponential stability of linear neutral differential systems with distributed delays [PDF]

, 2021
summary:We present new explicit criteria for exponential stability of general linear neutral time-varying differential systems. Particularly, our results give extensions of the well-known stability criteria reported in [3,11] to linear neutral time ...
Huy, Nguyen Dinh, Tran, Thai Bao, Ngoc, Pham Huu Anh, Thai Bao Tran, Nguyen Dinh Huy, Pham Huu Anh Ngoc   +5 more
core   +1 more source