Results 71 to 80 of about 4,012,994 (361)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Asymptotical stability analysis of conformable fractional systems
Journal of Taibah University for Science, 2020 In this paper, we analyses the asymptotical stability of the system in the form ${T_\alpha }y(\tau ){ = A}y(\tau ) + f(\tau ,y(\tau )) $ with the initial value $y({\tau _0}) = {y_0} $.
Yongfang Qi, Xuhuan Wang
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
New Conditions for the Exponential Stability of Pseudolinear Difference Equations in Banach Spaces
Abstract and Applied Analysis, 2016 We study the local exponential stability of evolution difference systems with slowly varying coefficients and nonlinear perturbations. We establish the robustness of the exponential stability in infinite-dimensional Banach spaces, in the sense that the ...
Rigoberto Medina
doaj +1 more source
Journal of Inequalities and Applications, 2017 The main purpose of this paper is to investigate the strong convergence and exponential stability in mean square of the exponential Euler method to semi-linear stochastic delay differential equations (SLSDDEs).
Ling Zhang
doaj +1 more source
Global Exponential Attitude Tracking Controls on SO(3) [PDF]
, 2014 This paper presents four types of tracking control systems for the attitude dynamics of a rigid body. First, a smooth control system is constructed to track a given desired attitude trajectory, while guaranteeing almost semi-global exponential stability.
Lee, Taeyoung
core
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2010 This paper addresses the issue of mean square exponential stability of stochastic Cohen-Grossberg neural networks (SCGNN), whose state variables are described by stochastic nonlinear integrodifferential equations.
Chuangxia Huang, Lehua Huang, Yigang He
doaj +1 more source