Results 21 to 30 of about 605,495 (265)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

RGNet: A redried tobacco lamina grader network via spectral-spatial feature integration

Industrial Crops and Products
Redried tobacco lamina (RTL) grading still relies on inefficient and subjective manual assessment. This study tackles the data scarcity and subjective grading challenges by first constructing a standardized high-quality image dataset of RTL.
Yuemao Wang, Rongdao Bi, Lei Ding, Qingong Ning, Wei Liu, Shuai Ma, Bo Ye   +6 more
doaj   +1 more source

Export Support by Regions: Experience of the Republic of Tatarstan

Управленческое консультирование, 2021
The article presents an argument for participation of federative units in the formation of the territories’ export potential and determines the main directions of organizing support for exporters on regional level.Article studies the variety of ...
R. R. Gimatdinov
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Development of an On-Site Protocol to Identify the Adulterations in Palmyrah Jaggery through Comparative Evaluation of Fresh Market samples and Control Sample

International Journal on Food, Agriculture and Natural Resources
Palmyrah jaggery, a traditional sweetener valued for its nutritional qualities, is susceptible to adulteration, compromising its authenticity and safety. This study aimed to develop a simple, cost-effective on-site protocol by examining the relationships
Kirushanthi Thangavel, Thavapiraja Thavaputhalvan, Vidana Gayan Gamage Chandrajith, Maathumai Sivaji, Srithayalan Srivijeindran   +4 more
doaj   +1 more source

Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review

Heliyon, 2021
The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) play a crucial role in cellular redox and metabolic system. Activation of Nrf2 may be an effective therapeutic approach for neuroinflammatory disorders, through activation of
Sanjiv Singh, Devarapati Nagalakshmi, K.K. Sharma, V. Ravichandiran   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A further examination of the export-led growth hypothesis [PDF]

This paper challenges the common view that exports generally contribute more to GDP growth than a pure change in export volume, as the export-led growth hypothesis predicts. Applying panel cointegration techniques to a production function with non-export
Dreger, Christian, Herzer, Dierk
core   +4 more sources