Results 41 to 50 of about 605,495 (265)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

First in CIS systems of metal bottom purging by inert gases in arc steel-melting furnace

Литьë и металлургия, 2001
Systems of “direct” and “hidden” types of bottom^ purging of metal by inert gases in a powerful arc steel-melting furnace are investigated and implemented.
M. P. Guljaev, V. V. Filippov, I. V. Ivanov, V. V. Enders, Ev. Shumacher, Ed. Shumacher, R. Franzki, X. Brener   +7 more
doaj  

Comparación de suadero de los Estados Unidos de América y de México con y sin tratamiento de marinación

Revista Mexicana de Ciencias Pecuarias, 2016
El objetivo de este estudio fue evaluar las características sensoriales, la suavidad y la pérdida durante el cocinado del suadero marinado (MR) y sin marinar (NM) procedente de México y EE.UU.
Nelson Huerta Leidenz, María Salud Rubio Lozano, Cheyenne Dixon, Alejandra Valdez, Keith Belk, Scott Howard, Franciso Alejandro Ruíz López   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Korea’s Export Structure and Its Determinants: A Comparison between 1990 and 2000 Exports [PDF]

Пространственная экономика, 2007
The process of Republic of Korea’s export structure transformation in 1990 and 2000 is studied. Changes in significance of basic export items and export markets are analyzed. Indices of trade complementarity of each trading partner, as well as indices of
Lee Jae-Woo
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Potential of neglected and underutilized seed crops: a bibliometric analysis

Discover Agriculture
Neglected and underutilized seed crops (NUSC) can play an important role in food and nutritional security. Understanding the progress and gaps in research concerning NUSC can improve the efficiency of research and policies involving the transformation of
Eranga M. Wimalasiri, P. W. M. Tharindi, Hiruni Nayakarathne, M. D. Anuradha, A. D. Ampitiyawatta, Ebrahim Jahanshiri, Upaka Rathnayake   +6 more
doaj   +1 more source