Results 51 to 60 of about 533,596 (298)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

HOW TO EVALUAT EFFICIENCY OF THE EXPORT STRATEGIES

Globalization and Business, 2018
The paper reviews the specific topics of the formulation and management of the Export Strategies. Export Strategies became of vital importance for Georgia. After the signing DCFTA with EU Georgian officials were wondering that the export potential of Georgia would be utilized in the best possible way.
GIORGI GAGANIDZE, BADRI RAMISHVILI
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

INTER-COUNTRY EFFICIENCY EVALUATION IN INNOVATION ACTIVITY ON THE BASIS OF METHOD FOR DATA ENVELOPMENT ANALYSIS AMONG COUNTRIES WITH DEVELOPED AND DEVELOPING ECONOMY, INCLUDING THE REPUBLIC OF BELARUS

Наука и техника, 2016
The paper considers a problem on efficiency evaluation of innovation activity in 63 countries with developed and developing economies while using a method for data envelopment analysis.
I. V. Zhukovski, A. B. Gedranovich
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Surface and lightning sources of nitrogen oxides over the United States: Magnitudes, chemical evolution, and outflow [PDF]

, 2007
We use observations from two aircraft during the ICARTT campaign over the eastern United States and North Atlantic during summer 2004, interpreted with a global 3-D model of tropospheric chemistry (GEOS-Chem) to test current understanding of regional ...
Avery, M A, Bertram, T H, Brune, William H, Cohen, Ronald C, Dibb, Jack E., Flocke, F, Fried, A, Gilliland, A B, Holloway, J S, Hudman, R C, Jacob, D J, Leibensperger, Eric M, Murray, L T, Neuman, J A, Orville, R, Perring, A E, Ren, Xinrong, Sachse, G W, Singh, H B, Swanson, Aaron L, Turquety, S, Wooldridge, Paul J, Wu, S   +22 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Exports and firm-level efficiency in African manufacturing [PDF]

, 2000
In this paper, we use firm-level panel data for the manufacturing sector in four African countries to estimate the effect of exporting on efficiency. Measures of firm-level efficiency using stochastic production frontier models are constructed for the period 1992 to 1995.
Arne Bigsten, Paul Collier, Stefan Dercon, Marcel Fafchamps, Bernard Gauthier, Jan Willem Gunning, Jean Habarurema, Abena Oduro, Remco Oostendorp, Catherine Pattillo, Måns Söderbom, Francis Teal, Albert Zeufack   +12 more
openaire   +2 more sources

Improving the efficiency of grain exports by processing organisations

IOP Conference Series: Earth and Environmental Science, 2023
Abstract Increasing the efficiency of agricultural production and its processing is a priority since the farming industry provides the population with the necessary food. The provision of the domestic market with processing products of the crop industry and its high competition is forcing domestic flour milling organisations to pay more ...
Sergei L Sokolov, Sergei A Shelkovnikov, Anatoly T Stadnik, Anastasia A Samokhvalova, Dmitrii V Essaulenko   +4 more
openaire   +1 more source