Results 21 to 30 of about 15,605 (265)

The Statistical Analysis and Forecasting of Ukraine’s Export

open access: yesСтатистика України, 2018
In the article the author determined the main directions of foreign economic activity of the country and was established that the main course for Ukraine is foreign trade and international investment activity.
G. V. Golubova
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Long-term Development of Time Series in Foreign Trade of the Czech Republic According to SITC Categories

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2004
This contribution presents results obtained by means of a time series analysis of import, export, turnover, balance of trade, coverage indicator of export with import, according to SITC classes (3rd Rev.) in the Czech Republic for time interval 1993-2001.
Jana Stávková, Erich Maca
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

«TRADE TERMS» EFFECT ON THE UKRAINIAN PAYMENT BALANCE STATE

open access: yesФінансово-кредитна діяльність: проблеми теорії та практики, 2020
. The «trade terms» effect as one of the main factors which causes the loss of Ukraine’s income from foreign trade is considered in the research paper. Quantitative assessment calculation of the Ukrainian economy losses gives rather obvious idea of the ...
A. Nepran   +4 more
doaj   +1 more source

International patent applications and innovation in South Africa

open access: yesSouth African Journal of Economic and Management Sciences, 2021
Background: Experts recommend support to patents for stimulating innovation. Also, the South African government supports patents, in particular, international patents. In this paper it is examined how this strategy can be designed to successfully trigger
Ulrich Schmoch, Anastassios Pouris
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

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