Results 41 to 50 of about 1,923,982 (307)

International patent applications and innovation in South Africa

South African Journal of Economic and Management Sciences, 2021
Background: Experts recommend support to patents for stimulating innovation. Also, the South African government supports patents, in particular, international patents. In this paper it is examined how this strategy can be designed to successfully trigger
Ulrich Schmoch, Anastassios Pouris
doaj   +1 more source

The impact of trade liberalisation on exports, imports and the balance of payments in selected developing countries [PDF]

, 2022
Trade liberalisation is assumed to improve a country’s performance by promoting domestic economic efficiency and by encouraging trade flows between nations, according to the supply side/orthodox plethora of studies. The limited empirical evidence related to the balance of payments and trade liberalisation that exists suggests that import flows respond ...
openaire   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Evidence Regarding Ethiopia's Import-Export of Mushrooms

Indonesian Journal of Social and Environmental Issues, 2022
Ethiopia has favorable agro-climate, topography, relatively low-cost labor, and rich fungal biodiversity. However, the country has a poor response to mushroom production and hence, currently, a huge amount of mushrooms is imported to the country ...
Tensaye Abate, Gonche Girma, Shiferaw Alem   +2 more
doaj   +1 more source

The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress [PDF]

Journal of The Royal Society Interface, 2015
Zinc is essential for life, but toxic in excess. Thus all cells must control their internal zinc concentration. We used a systems approach, alternating rounds of experiments and models, to further elucidate the zinc control systems in Escherichia coli .
Takahashi, Hiroki, Oshima, Taku, Hobman, Jon L., Doherty, Neil, Clayton, Selina R., Iqbal, Mudassar; id_orcid 0000-0002-5006-4331, Hill, Philip J., Tobe, Toru, Ogasawara, Naotake, Kanaya, Shigehiko, Stekel, Dov J.   +10 more
openaire   +3 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

THE IMPACT OF IMPORT-EXPORT ON ECONOMIC GROWTH IN MADAGASCAR

Journal of Smart Economic Growth, 2020
This study investigates the causal relationship between import-export and economic growth in Madagascar by applying Johansen co-integration test and VAR causality model for annual time series data over the period 1975-2017.
Etahisoa
doaj  

PASTA‐ELN: Simplifying Research Data Management for Experimental Materials Science

Advanced Engineering Materials, EarlyView.
Research data management faces ongoing hurdles as many ELNs remain complex and restrictive. PASTA‐ELN offers an open‐source, cross‐platform solution that prioritizes simplicity, offline access, and user control. Its in tuitive folder structure, modular Python add‐ons, and open formats enable seamless documentation, FAIR data practices, and easy ...
S. Brinckmann, G. Winkens, R. Schwaiger
wiley   +1 more source

DigiChrom: A Domain Ontology for Semantic Representation of Trivalent Chromium Platings and Its Large Language Model‐Based Alignment With Multiple Mid‐Level Ontologies

Advanced Engineering Materials, EarlyView.
Digitalizing electroplating requires both domain knowledge and interoperability. This work introduces PlatOn, a domain ontology for trivalent chromium plating and coating characterization, and a hybrid pipeline that aligns it to a mid‐level reference ontology by combining eight similarity metrics with language model reasoning. Expert‐validated mappings
Janik Harter, Elena Garcia Trelles, Christoph Schweizer, Thomas Seifert, Christoph Baumer, Mahmoud Elkady, Katja Feige, Daniel Grimme, Edgar Hoffmann, Andreas Waibel, Anke Walter   +10 more
wiley   +1 more source