Results 261 to 270 of about 11,408,171 (332)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Physicochemical and Mechanical Characterization of HDPE and LDPE Films Used in the Postharvest Packaging of Banana (<i>Musa paradisiaca</i>). [PDF]

Polymers (Basel)
Ruiz Medina MD, Ruales J.
europepmc   +1 more source

Magnetically Responsive Piezoelectric Nanocapacitors Enhance Neural Recovery Following Spinal Cord Injury via Targeted Spinal Magnetic Stimulation

Advanced Science, EarlyView.
This study presents a novel “in vivo–in vitro” therapeutic strategy for spinal cord injury by leveraging magnetically responsive piezoelectric nanomaterials. These nanomaterials enable targeted delivery of localized electrical stimulation at the injury site through noninvasive external magnetic actuation, thereby promoting axonal regeneration and ...
Zhihang Xiao, Tingting Li, Lechi Zhang, Chunya Xia, Zelin Su, Xuyan Ren, Yingjie Fan, Zerui Wu, Yaobo Liu, Min Su   +9 more
wiley   +1 more source

Food businesses and export requirements: a first glance at current perception and future expectations. [PDF]

Ital J Food Saf
Gori A, Armani A, Tinacci L, Noè P, Santini N, Tognetti D, Nuvoloni R.   +6 more
europepmc   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

PIC-SURE: an open-source platform for integrating clinical and genomic data. [PDF]

NPJ Digit Med
Gutiérrez-Sacristán A, Hughes EE, Amari R, Colon G, DeSain TN, Neely S, Peck JT, Piatt S, Sikina L, Lyons J, Pillion D, Avillach P.   +11 more
europepmc   +1 more source

From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

Advanced Science, EarlyView.
A comprehensive technology platform enables high‐fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi‐automated computational framework for 3D reconstruction, voxel‐instead of pixel‐based biomarker discovery, and immersive mixed reality data exploration.
Stefania Alexandra Iakab, Jonas Cordes, Thomas Enzlein, Florian Keller, Kevin Kastner, Theresa Mulholland, Björn Christian Fröhlich, Lars Gruber, James Lucas Cairns, Stefan Schmidt, Mathias Hafner, Richard Schneider, Johannes Betge, Frank Fischer, Julian Reichwald, Rüdiger Rudolf, Carsten Hopf   +16 more
wiley   +1 more source

Smart Image-Based Deep Learning System for Automated Quality Grading of Phalaenopsis Seedlings in Outsourced Production. [PDF]

Sensors (Basel)
Lin HD, Zhang ZY, Lin CH.
europepmc   +1 more source

Multi‐Dimensional Acoustic Cascaded Holographic Encryption with Instantaneous Visual Decryption via Particle Manipulation

Advanced Science, EarlyView.
Acoustic holograms act as key tools for information encryption, yet current schemes limit encryption dimensionality/security and require time‐consuming decryption. A compact device integrates multi‐dimensional cascaded acoustic holography with particle manipulation, employs extra secret keys, enables rapid decryption, and is validated via 1D/2D/3D ...
Qin Lin, Feiyan Cai, Yunqing Liu, Zejiao Zhou, Jiayang Li, Rujun Zhang, Hongpeng Chen, Hairong Zheng, Huailing Zhang   +8 more
wiley   +1 more source

A multi-regional input-output database linking Chinese subnational regions and global economies. [PDF]

Sci Data
Hou X, Zheng J, He M, Feng G, He K, Ma T, Coffman D, Mi Z, Wang S.   +8 more
europepmc   +1 more source