Results 221 to 230 of about 8,948,174 (312)

THE DEVELOPMENT OF REGIONAL EXPORT POTENTIAL

NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF KAZAKHSTAN, 2019
Мadina Karimbergenova, Аinash Nurgaliyeva, Galymzhan Kerimbek, Sergey Bespalyy, Luiza Moldashbayeva   +4 more
openaire   +1 more source

Non-Human Primates as Sentinels and Reservoirs of Emerging Zoonotic Diseases in Indonesia: A One Health Perspective on Pathogen Spillover, Surveillance Gaps, and Regulatory Frameworks. [PDF]

J Med Primatol
Sophian A.
europepmc   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma. [PDF]

Signal Transduct Target Ther
Horzum U, Oberacher H, Haun M, Geley S, Roman-Trufero M, Auner H, Martowicz A, Untergasser G, Gunsilius E, Willenbacher W, Yanik H, Esendagli G, Wolf D, Farhan H.   +13 more
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Microbial interactions as key players shaping the emergence and spread of <i>de novo</i> resistance mutations. [PDF]

Microbiology (Reading)
Pittaccio L, Knowles J, Wheatley RM.
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

siRNA-guided DNA-methylation at a sucrose transporter gene potentially contributes to climatic plant adaptation. [PDF]

PLoS Biol
Li J, Song M, Xu Q, Tang Y, Liesche J.
europepmc   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Quantifying the Impact of Winter Cover Crops on Sediment Export in Small Agricultural Watersheds and Beyond. [PDF]

Environ Manage
Pruitt AN, Tank JL, Speir SL, Mahl UH, Aboelnour M, Vincent AES, Royer TV.   +6 more
europepmc   +1 more source